Changes

*** E.g the lungs, [[Liver - Anatomy & Physiology|liver]] , [[Spleen - Anatomy & Physiology|spleen]], kidney and brain.

*** E.g the lungs, [[Liver - Anatomy & Physiology|liver]] , [[Spleen - Anatomy & Physiology|spleen]], kidney and brain.

*** Form secondary tumours in these organs.

*** Form secondary tumours in these organs.

* Neoplastic [[Thrombosis - Pathology#Thromboembolism|thromboembolism]] is often involved.

* Neoplastic [[Thromboembolism|thromboembolism]] is often involved.

====Transcoelomic Spread====

====Transcoelomic Spread====

** Where tumours are large, there may be much necrotis tissue, which can ave a toxic effect.

** Where tumours are large, there may be much necrotis tissue, which can ave a toxic effect.

** Secondary haemorrhagic syndromes and depression of bone marrow function may occur.

** Secondary haemorrhagic syndromes and depression of bone marrow function may occur.

*** Result in with anaemia and [[Thrombosis - Pathology#Disseminated Intravascular Coagulation|disseminated intravascular coagulation]].

*** Result in with anaemia and [[Disseminated Intravascular Coagulation|disseminated intravascular coagulation]].

===Death===

===Death===

*#* E.g. neuropathies, cerebellar degeneration, encaphalitis.

*#* E.g. neuropathies, cerebellar degeneration, encaphalitis.

*# Bone marrow malfunction.

*# Bone marrow malfunction.

*#* E.g. [[Haemorrhage - Pathology#Purpura|purpuric disease]], anaemia, [[Thrombosis - Pathology#Disseminated Intravascular Coagulation|disseminated intravascular coagulation]].

*#* E.g. [[Haemorrhage - Pathology#Purpura|purpuric disease]], anaemia, [[Disseminated Intravascular Coagulation|disseminated intravascular coagulation]].

===Endocrine Aspects===

===Endocrine Aspects===