Changes

Jump to navigation Jump to search
Line 30: Line 30:  
===Pathology===
 
===Pathology===
 
====Pathogenesis====
 
====Pathogenesis====
*Infects and replicates in the oropharynx
+
Canine adenovirus 1 (CAV1) initially infects and replicates in the cells of the oropharynx, before establishing a viraemia. A tropism for endothelial cells exists, leading to attack of the liver sinusoids and the lining of the gall bladder. Kuppfer cells are also affected. This results in hepatitis.
*Viremia as the virus reaches endothelial cells
+
In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.
*Attacks the endothelial lining of '''gall bladder''', '''liver sinusoids''', and '''Kuppfer cells'''
  −
*Resulting '''heptatitis''' is followed by severe abdominal pain and often death
  −
*Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder
  −
*In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis
  −
*In foxes: virus replicates in the endothelia of the brain resulting in neuronal damage, fits, and paralysis
   
====Gross====
 
====Gross====
 
*the virus has a tropism for endothelium and hepatocytes
 
*the virus has a tropism for endothelium and hepatocytes
Line 48: Line 43:  
**wall usually shows oedema (up to 2cm diameter)
 
**wall usually shows oedema (up to 2cm diameter)
 
*[[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Tonsils - Anatomy & Physiology|tonsils]] are enlarged and reddened, sometimes haemorrhagic
 
*[[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Tonsils - Anatomy & Physiology|tonsils]] are enlarged and reddened, sometimes haemorrhagic
 +
*Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder
 +
*In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis
 
====Microscopically====
 
====Microscopically====
 
*basophilic intranuclear inclusion bodies
 
*basophilic intranuclear inclusion bodies
 
**in hepatocytes and macrophages
 
**in hepatocytes and macrophages
 +
 
==Treatment==
 
==Treatment==
 
===Control===
 
===Control===
6,502

edits

Navigation menu