Changes

*The lesions are proliferative to degenerative, depending on the virus strain.   

*The lesions are proliferative to degenerative, depending on the virus strain.   

*The skin tumors result from proliferation of undifferentiated mesenchymal cells which become large stellate cells (myxoma cells).  These cells may contain intracytoplasmic eosinophilic inclusions. These cells lie in a homogeneous matrix of mucinous material interspersed with capillaries and inflammatory cells.  Endothelial proliferation with narrowing of the lumen and extrusion of stellate "myxoma" cells has been described.   

*The skin tumors result from proliferation of undifferentiated mesenchymal cells which become large stellate cells (myxoma cells).  These cells may contain intracytoplasmic eosinophilic inclusions. These cells lie in a homogeneous matrix of mucinous material interspersed with capillaries and inflammatory cells.  Endothelial proliferation with narrowing of the lumen and extrusion of stellate "myxoma" cells has been described.   

*Epithelial cells overlying the tumor may show hyperplasia or degeneration, or may appear normal.  Epithelial proliferation is characterized by ballooning of cells in the stratum granulosum and hyperkeratosis.  Epithelial vesiculation progresses to crust formation.  Large, eosinophilic, intracytoplasmic inclusions are especially prominent in the stratum spinosum.  Lesions in other organs include cellular proliferation of alveolar epithelium and the reticulum cells of [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Spleen - Anatomy & Physiology|spleen]].  Focal hemorrhage may be present in skin, kidneys, lymph nodes, testes, heart, stomach, and intestinal walls.  Myxoma cells may be present in [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Bone Marrow - Anatomy & Physiology|bone marrow]], uterus, ovaries, testes, and lungs.

*Epithelial cells overlying the tumor may show hyperplasia or degeneration, or may appear normal.  Epithelial proliferation is characterized by ballooning of cells in the stratum granulosum and hyperkeratosis.  Epithelial vesiculation progresses to crust formation.  Large, eosinophilic, intracytoplasmic inclusions are especially prominent in the stratum spinosum.  Lesions in other organs include cellular proliferation of alveolar epithelium and the reticulum cells of [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Spleen - Anatomy & Physiology|spleen]].  Focal hemorrhage may be present in skin, kidneys, lymph nodes, testes, heart, stomach, and intestinal walls.  Myxoma cells may be present in lymph nodes, bone marrow, uterus, ovaries, testes, and lungs.

*Virus multiplication and tumor-like lesions occur initially at the site of intradermal inoculation   

*Virus multiplication and tumor-like lesions occur initially at the site of intradermal inoculation   

*This is followed by spread to regional lymph nodes and cell-associated viremia, with generalization to the skin and internal organs

*This is followed by spread to regional lymph nodes and cell-associated viremia, with generalization to the skin and internal organs

*Gelatinous proliferative nodules all over body, especially at '''orifices''' (eyes, anus, nose)

*Gelatinous proliferative nodules all over body, especially at orifices (eyes, anus, nose)

*Rabbit dies within 12 days, if not killed by predators

*Rabbit dies within 12 days, if not killed by predators