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| <gallery> | | <gallery> |
− | Image:Basenji.jpg|'''Basenji'''<p>WikiCommons | + | Image:Basenji.jpg|'''Basenji'''<p><small>Copyright Sannse 2003 Wikimedia Commons |
− | Image:Shar_pei.jpg|'''Shar Pei'''<p>WikiCommons | + | Image:Shar_pei.jpg|'''Shar Pei'''<p><small>Copyright Wrinkle 2009 Wikimedia Commons |
− | Image:Soft_coated_wheaten_terrier.jpg|'''Soft Coated Wheaten Terrier'''<p>WikiCommons | + | Image:Soft_coated_wheaten_terrier.jpg|'''Soft Coated Wheaten Terrier'''<p><small> Copyright Pleple2000 2006 Wikimedia Commons |
− | Image:Yorkshire_Terrier.jpg|'''Yorkshire Terrier'''<p>WikiCommons | + | Image:Yorkshire_Terrier.jpg|'''Yorkshire Terrier'''<p><small> Copyright Jlcerso 2007 Wikimedia Commons |
| </gallery> | | </gallery> |
| | | |
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| ===Laboratory Tests=== | | ===Laboratory Tests=== |
| + | Changes consistent with possible differential diagnoses, such as hepatic and renal disease, should also be ruled out. |
| + | |
| ====Haematology==== | | ====Haematology==== |
| *[[Changes in Inflammatory Cells Circulating in Blood - Pathology #Lymphopenia|'''Lymphopaenia]]''' occurs with lymphangiectasia due to the loss of lymph. | | *[[Changes in Inflammatory Cells Circulating in Blood - Pathology #Lymphopenia|'''Lymphopaenia]]''' occurs with lymphangiectasia due to the loss of lymph. |
| | | |
| ====Biochemistry==== | | ====Biochemistry==== |
− | *'''Panhypoproteinaemia''' | + | *'''Panhypoproteinaemia''' is a pattern more suggestive of PLE since albumin is usually lost in excess of globulin in protein losing nephropathy. Hypoproteinaemia may also develop with haemorrhage, dermal protein loss (after severe burns of degloving injury) or if the rate of synthesis of albumin is reduced by a severe hepatic insult. Oedema and ascites typically develop when serum albumin concentration drops below 15 g/l. |
− | **Hypoglobulinaemia with hypoalbuminaemia is a pattern more suggestive of PLE.
| |
− | **Albumin is usually lost in excess of globulin in protein losing nephropathy.
| |
| *'''Hypocholesterolaemia''', especially in lymphangiectasia. | | *'''Hypocholesterolaemia''', especially in lymphangiectasia. |
| *[[Hypocalcaemia - Small Animal|'''Hypocalcaemia''']] | | *[[Hypocalcaemia - Small Animal|'''Hypocalcaemia''']] |
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| ==Treatment== | | ==Treatment== |
− | Treatment of the underlying cause of disease should be initiated, if possible. | + | Treatment of the underlying cause of disease should be initiated, if possible. In the case of severe respiratory embarrassment, treatment should be directed at draining any pleural effusion and providing support in case of a pulmonary thromboembolus. |
| | | |
| ====Plasma transfusion==== | | ====Plasma transfusion==== |
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| ==References== | | ==References== |
| + | *Littman MP, Dambach DM, Vaden SL, Giger U (2000) '''Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997)''' ''J Vet Intern Med. 2000 Jan-Feb;14(1):68-80.'' |
| *Ettinger, S.J. and Feldman, E. C. (2000) '''Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2''' (Fifth Edition) ''W.B. Saunders Company''. | | *Ettinger, S.J. and Feldman, E. C. (2000) '''Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2''' (Fifth Edition) ''W.B. Saunders Company''. |
| *Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''. | | *Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''. |