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Metacercariae excyst → immature flukes present in the small intestine → migrate across the peritoneal cavity (about 1 week) → to the liver → migrate through the liver parenchyma for 6-7 weeks becoming more destructive as they grow → enter bile ducts
Metacercariae excyst → immature flukes present in the small intestine → migrate across the peritoneal cavity (about 1 week) → to the liver → migrate through the liver parenchyma for 6-7 weeks becoming more destructive as they grow → enter bile ducts
*The prepatent period is 10-12 weeks
*The prepatent period is 10-12 weeks
===Acute Fascioliasis===
The acute disease is a less common type of Fasciola hepatica, and generally occurs 2-6 weeks after large ingestion of metacercariae. The young liver flukes migrate through the liver parenchyma causing severe haemorrhaging, due to the damage to the [[Liver - Anatomy & Physiology|liver]] vasculature.
This occurs in late autumn and winter, mainly between the months of August to October. Outbreaks of acute fascioliasis usually present as sudden deaths. On examination infected animals are weak, with pale mucous membranes. They may also have enlarged livers, and the liver surface may be cover with a fibrinous peritonitis, particularly evident on the ventral lobe. Tracts become filled with blood and degenerate hepatocytes later infiltrated with [[Eosinophils|eosinophils]], [[Lymphocytes|lymphocytes]] and replaced by fibrosis.
[[Image:Fasciola hepatica - bile duct.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Flukeman, Wikimedia Commons) ''']]
===Subactute Fascioliasis===
This is caused by ingestion of metacercariae over a longer period of time. Some may have migrated to the bile ducts, causing [[cholangitis]], whilst other metacercariae are migrating through the liver causing lesions similar to those present in acute fascioliasis. The infected host may present with severe haemorrhagic anaemia, with [[hypoalbuminaemia]], rapid loss of body condition, reduced appetite, pale mucous membranes, and submandibular oedema may also be present. On post-mortem, an enlarged liver is common and haemorrhagic tracts are usually visible on the liver surface. If left untreated, it is often fatal. This form of fascioliasis occurs around 6-10 weeks after ingestion of the metacercariae by the host, and like acute fascioliasis occurs in late autumn and winter.
===Chronic Fascioliasis===
This is usually seen in late winter, early spring and is currently the most common fascoloiasis seen. It occurs around 4-5 months after ingestion of the metacercariae. Hypochromic and macrocytic anaemia and hypoalbuminaemia are common, as the adult flukes are capable of sucking up to 0.5ml of blood each day. In heavy infections, this can prove to be a severe loss.
Infected animals may present with progressive loss of body condtion, reduced appeptite, which along with hypoalbuminaemia can result in an gaunt animal. Other common signs include pale mucous membranes, and submandibular oedema, more commonly known as 'bottle jaw.' On biopsy the liver will have an irregular shape, distorted shape with areas of fibrous tissue replacing the cells damaged by the migrating flukes. The bile ducts appear dilated, and dark, and it is often possible to express numerous numbers of adult flukes from within the ducts. Pathology is similar in both sheep and cattle, expect in cattle you may see calcification of the bile ducts, and enlargement of the gall bladder. The calcified bile ducts are often seen protruding from the liver surface, which is known as 'pipe stem liver.'
==== Pathogenesis of acute fasciolosis ====
==== Pathogenesis of acute fasciolosis ====
=== Diagnosis ===
=== Diagnosis ===
This is performed primarily on the clinical findings, seasonal occurance, as well as a previous history of fasciolosis on the farm. These along with post-mortem form the basis for diagnosis of Fasciola hepatica. In practice, diagnosis of ovine fasciolosis is often more straightforward than bovine fasciolosis.
Examination of faeces for liver fluke eggs is also useful, and may be complemented by laboratory tests. Firstly the measurement of Glutamate dehydrogenase (GLDH) is used. This is an enzyme released by damaged hepatic cells, and levels become elevated within the first few weeks of infection. Another test commonly used is measuring the glutamyl transpeptidase (GGT), and this indicates damage to the epithelial cells of the bile ducts, and is seen later in the cycle, and maintained for a longer duration.
An [[ELISA]] can also be used in the detection process. It identifies antibodies against flukes in the serum and milk samples, and is deemd to be extremely reliable in this case.
'''Acute fasciolosis'''
'''Acute fasciolosis'''
*Clincal history
*Clincal history
'''Alternative strategies'''
'''Alternative strategies'''
*An ability to recognise and define the extent of snail habitats allows alternative cost-effective control options such as fencing and drainage
*An ability to recognise and define the extent of snail habitats allows alternative cost-effective control options such as fencing and drainage
===Treatment===
If the fuke is present treat with triclabendazole, which is effective against all stages of Fasciola hepatica. Treatment should be applied in September/October and again in January, if faecal egg count is still postitive. One may also treat against adult only stages in May/June, preventing any future pasture contamination. However, do not use the same treatment in September/October as used in May/June, as resistance to drugs is becoming a real problem within the UK due to overuse. If it has been a particularly wet season, it may be necessary to treat again, as Fasciola hepatica becomes more prevalent under such conditions.
Isolation and treatment of all new animals entering from another farm has also be shown to be effective. Other control measures include fencing off wet areas, and increasing soil drainage.
[[Fasciola hepatica]]
[[Fasciola hepatica]]