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==Description==
This term refers to the perforation of all layers of the oesophagus and the leakage of air and ingesta into the surrounding tissues. The contents of the oesophagus are not sterile and bacteria are seeded into surrounding tissues when the oesophagus is ruptured. For most of its length, the oesophagus runs through the thoracic cavity within the mediastinum, meaning that ruptures in this location cause septic '''mediastinitis''' and '''pneumomediastinum'''. The mediastinum is continuous with the fascial planes of the neck and the spread of air and bacteria into this region leads to '''subcutaneous emphysema''' and '''cellulitis'''. It has been suggested that the spread of infection along fascial planes may be assisted by the motion of peristalsis or of pulsation in the carotid arteries. If the parietal pleural membrane (which lines the mediastinum) is also ruptured, infection and air can enter the pleural space (between the parietal and visceral pleurae), causing '''pyothorax''' and '''pneumothorax'''. If more air is drawn into the mediastinum or pleural cavity through the rupture during each inspiratory phase but not expelled during exhalation, a '''tension pneumothorax''' may develop, in which the contents of the thorax are gradually compressed by the accumulation of air. Finally, if the perforation is caused by a sharp object in the region of the heart base, the great vessels arising from the heart may be lacerated causing '''fatal internal haemorrhage'''.
Perforation may occur when sharp [[Oesophageal Foreign Body|foreign bodies]] become lodged in the oesophagus or when attempts are made to remove these objects endoscopically or surgically.
==Diagnosis==
For a more complete description of oesophageal foreign bodies and their sequelae, see [[Oesophageal Foreign Body|here]]. The following sections refer specifically to the diagnosis and treatment of oesophageal ruptures.
===Clinical Signs===
These may include:
*'''Dyspnoea''' due to pleural effusion (with pyothorax), pneumothorax or tension pneumothorax.
*'''Subcutaneous emphysema''' over the neck and pectoral region.
*'''Pyrexia''', depression, inappetence and lethargy due to infection and the acute phase response to inflammation.
*'''Collapse''' when stressed due to the absence of any respiratory reserve function or due to internal haemorrhage.
===Diagnostic Tests===
A blood haematological profile may indicate signs of severe acute inflammation, including '''neutrophilic leucocytosis''' with a right or left shift. In severe cases, a leukaemoid response (with exuberant mobilisation of neutrophils from the bone marrow storage pool) may be observed. Markers of acute inflammation (such as '''fibrinogen''') will also be elevated.
===Diagnostic Imaging===
'''Plain radiographs''' of the chest may show:
*'''Pleural effusion''' with contracture of the lung lobes and presence of radiodense material around and between lobes.
*'''Pneumothorax''' or '''tension pneumothorax'''. If the latter condition is unilateral, a dorso-ventral radiograph will show that the contents of the mediastinum are pushed to one side by the expansion of the lung field on the affected side.
*'''Expansion of the mediastinum''', best assessed on a dorso-ventral radiograph where the mediastinum will appear to be significantly wider than the vertebral column.
*'''Emphysema''' in the fascial planes of the neck.
'''Ultrasonography''' can be used to better assess the contents of the mediastinum and pleural space and to guide fine needle aspiration if samples are required.
[[Category:Oesophagus_-_Pathology]]
[[Category:Oesophagus_-_Pathology]]
[[Category:To_Do_-_James]]
[[Category:To_Do_-_James]]
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