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Feline Parvovirus kills the stem cells of the villi. The villi tip cells turnover normally but are not being replaced, leading to stunted villi and malabsorption.
Feline Parvovirus kills the stem cells of the villi. The villi tip cells turnover normally but are not being replaced, leading to stunted villi and malabsorption.
Clinical signs include pyrexia, severe enteritis (often bloody), dehydration, leukopenia, anemia.
Clinical signs include pyrexia, severe enteritis (often bloody), dehydration, leukopenia, and anemia.
Severe [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|vomiting]] and [[Diarrhoea|diarrhoea]] may also occur. This is often thin, watery and foul-smelling, but may also be blood-tinged.
Neonatal kittens less than 2 weeks show cerebellar hypoplasia. This leads to problems with coordination and balance.
Neonatal kittens less than 2 weeks show cerebellar hypoplasia. This leads to problems with coordination and balance.
The virus targets rapidly dividing cells: lymph nodes, bone marrow, crypts of small intestine. The breakdown of lymphoid tissue leads to a decreased white blood cell count, and destruction of lymphoid and myeloid stem cells.
The virus targets rapidly dividing cells: lymph nodes, bone marrow, crypts of small intestine. The breakdown of lymphoid tissue leads to a decreased white blood cell count, and destruction of lymphoid and myeloid stem cells.
Animals who have contracted the virus usually die despite treatment, due to the extensive dehydration.
====Epidemiology====
====Epidemiology====
Since the introduction of a vaccine, this disease is now relatively uncommonly seen.
Since the introduction of a vaccine, this disease is now relatively uncommonly seen.
Over the last 10/15 years this has been seen primarily in the cat, but it is now also seen [[Canine Parvovirus|in the dog]].
Over the last 10/15 years this has been seen primarily in the cat, but it is now also seen [[Canine Parvovirus|in the dog]].
===Pathology===
===Pathology===