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Antibiotic Responsive Diarrhoea (view source)
Revision as of 21:20, 15 July 2010
, 21:20, 15 July 2010no edit summary
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==Description==
'''Antibiotic responsive diarrhoea''' (ARD) describes a clinical syndrome which is associated with alterations in the population of enteric bacterial flora and in the response of the host immune system to these bacteria. It may occur independently of any other apparent pathological process ('''idiopathic''') but it occurs commonly with a number of intestinal diseases ('''secondary'''). The term 'antibiotic responsive diarrhoea' has replaced the previous description of '''small intestinal bacterial overgrowth''' (SIBO) due to uncertainty over the level at which enteric bacteria could be said to be present in excessive numbers and because an increased number of bacteria is not always the cause of the clinical syndrome described.
The mucosal immune system of the host and the enteric bacterial flora interact constantly in the gastro-intestinal (GI) tract. The host must remain tolerant of the enteric flora but must still be able to recognise and respond to potentially pathogenic organisms. These apparently contradictory tasks are resolved by the ability of the immune system to 'tolerate' certain antigens if these are presented to macrophages and dendritic cells in an appropriate manner.
In cases of idiopathic ARD, the only consistent clinical finding is responsiveness to antimicrobial therapy. This is found commonly, but not exclusively, in young [[Canine Breeds - WikiNormals #Pastoral Group|German Shepherd Dogs]] and it has been suggested that this is associated with a deficiency in [[IgA]] or with another form of immune dysregulation in this breed. However, the true underlying mechanism could be far more complex and numerous other hypotheses have been proposed. In cases of secondary ARD, there is usually an underlying intestinal disorder, of which the most common are:
*Increased concentrations of small intestinal substrates resulting from failure of host digestion or absorption
**[[Lymphangiectasia]] leads to increased luminal concentrations of fat and protein.
**[[Exocrine Pancreatic Insufficiency]] results in an inability to digest fat, protein and carbohydrate, leaving these substrates in the intestinal lumen.
**[[Villous Atrophy]] leads to the loss of digestive enzymes on the brush borders of enterocytes.
**[[Extrahepatic Biliary Obstruction]] leads to an inability to digest and absorb fat because bile salts do not pass into the intestine.
**Congenital deficiencies of brush border enzymes are very rare in animals.
*Altered GI motility causing changes in the population density of enteric microflora
**Partial intestinal obstruction due to the presence of foreign bodies, neoplastic masses or strangulations.
**Paralytic ileus
**Anatomical disorders which may be congenital or acquired (as with surgical removal of the ileo-caeco-colic junction allowing reflux of bacteria from the large to the small intestine.)
*Reduction in the concentration of factors that usually act to limit bacterial population growth
**Failure to produce gastric acid (achlorhydria) is rare in small animals, even with atrophic gastritis.
The consequences of ARD are numerous and these are only beginning to be explored fully. They include:
*Interference with fluid and nutritional absorption due to dysfunction of the enzymes located at the microvillous brush border. Depending on the cause of the ARD, this may worsen any concurrent maldigestion or malabsorption.
*Disturbances in mucosal permeability.
*Deconjugation of bile acids which reduces the ease with which they are removed from the circulation by the liver during enterohepatic recirculation. Hepatic bile acid synthesis must therefore increase to compensate. Deconjugated bile acids also irritate the colonic mucosa causing colitis and diarrhoea.
*Hydroxylation of fatty acids, which like deconjugated bile acids, are irritant to the colonic mucosa and cause colitis and diarrhoea.
==Description==
==Signalment==
Idiopathic ARD is common in young German Shepherd Dogs but secondary ARD may occur in any breed or age of dog depending on the underlying cause. ARD is thought to occur in cats but it is not well characterised in this species. It is suggested that the condition is much more common than previously suspected.
==Diagnosis==
ARD represents a very large diagnostic challenge as the condition is still difficult to define and because no single test offers an acceptable level of sensitivity or specificity. The manifestations of the disease are also extremely heterogenous, with some animals showing some of the recognised diagnostic features but not others. The condition is frequently suspected in animals that are thought to have one of the diseases that leads to secondary ARD but it is rarely confirmed by any meaningful test. This approach is far from ideal as it probably results in the overuse of antibiotics where they may not be necessary.
Primary ARD is generally diagnosed where there is a consistent signalment, history and clinical presentation and no other apparent underlying disease. In secondary ARD, the clinical signs may be difficult to separate from those of the underlying disease, especially in animals with maldigestion/malabsorption. The underlying disease is usually treated as a priority and the ARD may then resolve or it may require treatment with antibiotics.
===Clinical Signs===
===Clinical Signs===
German Shepherd dogs with idiopathic ARD may show the following clinical signs:
*Chronic small intestinal diarrhoea
*Chronic small intestinal diarrhoea
*Weight loss
*Weight loss
*Abdominal discomfort
*Abdominal discomfort
===Trial Therapy===
Ideally, if the history and clinical signs provide no obvious localisation, a full diagnostic investigation is recommended to define the cause of the condition. This would involve analysis of blood samples, examination of faecal and urine samples, diagnostic imaging and endoscopy and is therefore beyond the reach of most clients. Although less clinically rigorous, it may be justified to begin trial antimicrobial (antibacterial and antiparasitic) therapy at the outset instead to determine whether the condition does respond. This approach may still be appropriate if further diagnostic work is intended as the presence of secondary ARD may impede the diagnosis of any underlying cause. A suitable regime would include:
*Antiparasitic treatment to rule out helminths and protozoa. Fenbendazole is often used for this purpose.
*Antibacterial treatment with tylosin or metronidazole, continued for one month.
If this treatment does not result in any improvement, further investigations would be indicated to detect a primary GI disease. If the clinical signs respond to the therapy but recur when this is withdrawn, a diagnosis of ARD can be made with some confidence.
===Laboratory Tests===
Ideally, full routine routine haematology, biochemistry, urinalysis, faecal bacteriology and parasitology, diagnostic imaging and gastroduodenoscopy should be performed to identify any underlying disease. A trypsin-like immunoassay (TLI) can be used diagnose [[Exocrine Pancreatic Insufficiency|exocrine pancreatic insufficiency (EPI)]].
Traditionally, the gold standard direct test for diagnosing ARD has been culture of duodenal juice collected during endoscopy. Unfortunately, this is an expensive test and it is rarely available. However the major complaint to be made about duodenal juice culture is that it is currently not possible to define a normal control result in dogs and cats. The accepted figures for bacterial population density in the canine GI tract are based on extrapolations from similar studies in humans.
Indirect tests such as serum folate and cobalamin concentrations have been used to analyse the bacterial concentrations in small intestines. Some species of bacteria may increase the level of serum folate concentration or decrease serum cobalamin concentration, or both. The sensitivity and specificity of this test is low and therefore their use in the diagnosis of ARD is questionable.
Serum unconjugated bile acids
==Treatment==
==Treatment==
[[Category:Intestines,_Small_and_Large_-_Pathology]]
[[Category:Intestines,_Small_and_Large_-_Pathology]]
[[Category:To_Do_-_James]]
[[Category:To_Do_-_James]]
[[Category:Dog]][[Category:Cat]]