Changes

==History and Clinical Signs==

==History and Clinical Signs==

Spores pass through the wall of the GI tract and via the bloodstream enter the muscle where they then lie latent. Under the correct conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxins damage the capillaries causing a serosanguinous exudate. Muscle necrosis occurs due to gas producing bacteria resulting in emphysaema and crepitus

Spores pass through the wall of the GI tract and via the bloodstream enter the muscle where they then lie latent. Under the correct conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxins damage the capillaries causing a severe necrotising myositis.  

The bacteria can cause rapid toxaemia resulting in death, however if clinical signs do occur these can include toxaemia, pyrexia, depression, [[Lungs Circulatory - Pathology#Pulmonary oedema|pulmonary oedema]], circulatory collapse lameness and swollen hot muscles which later become cool as necrosis occurs.

The bacteria can cause rapid toxaemia resulting in sudden death, however if clinical signs do occur these can include toxaemia, pyrexia, depression, [[Lungs Circulatory - Pathology#Pulmonary oedema|pulmonary oedema]], circulatory collapse lameness and swollen hot muscles which later become cool as necrosis occurs.

==Pathology==

==Pathology==

In the early stages the musce periphery appears dark red and is Distended by serous or serosanguinous exudate. Is wet on the cut surface

In the early stages the musce periphery appears dark red and is distended by serous or serosanguinous exudate. Is wet on the cut surface

and the centre of the lesion is full of gas bubbles, porous, dry, reddish black

and the centre of the lesion is full of gas bubbles, porous, dry, reddish black. Additionally the muscle has a rancid odour.

*Histologically:

*Histologically:

In the early stages separation of the myofibres by exudate can be seen which progresses to [[Necrosis - Pathology#Coagulation Necrosis|Coagulative necrosis]] No nuclei

In the early stages separation of the myofibres by exudate can be seen which progresses to [[Necrosis - Pathology#Coagulation Necrosis|Coagulative necrosis]] No nuclei

 

[[Category:Sheep]][[Category:To_Do_-_Caz]]

[[Category:Sheep]][[Category:To_Do_-_Caz]]

==Treatment==

==Treatment==

==Prognosis==

==Prognosis==

==References==

==References==