Johne's disease refers to the condition caused by the mycrobacterial infection. Calves are most commonly affected by this condition, and can be infected via a number of routes. They may be infected by ingestion of infected manure, or via transmammary infection. In addition, calves may also be infected in vitro, or may ingest the bacteria via colostrum. | Johne's disease refers to the condition caused by the mycrobacterial infection. Calves are most commonly affected by this condition, and can be infected via a number of routes. They may be infected by ingestion of infected manure, or via transmammary infection. In addition, calves may also be infected in vitro, or may ingest the bacteria via colostrum. |