Changes

*'''Nitazoxanide, NTZ (Navigator, Idexx Pharmaceuticals)''': no longer commercially available in the US.  ''Mode of action'': a member of the 5-nitrothiazole class of antiparasitics that inhibits the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction essential for anaerobic energy metabolism.(IVIS 4)  ''Efficacy'': 60% success rate in an FDA-regulated study.(98 in Furr) ''Potential adverse effects'': adverse effects and death at high doses(98), fever, anorexia, diarrhoea, lethargy, depression and laminitis recorded at lower doses.  Toxic signs usally resolve upon cessation of treatment.(Furr)'''''Caution''': 'administration of nitazoxanide can disrupt the normal microbial flora of the gastrointestinal tract leading to enterocolitis.  Deaths due to enterocolitis have been observed while administering the recommended dose in field studies.''''''(IVIS 4)

*'''Nitazoxanide, NTZ (Navigator, Idexx Pharmaceuticals)''': no longer commercially available in the US.  ''Mode of action'': a member of the 5-nitrothiazole class of antiparasitics that inhibits the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction essential for anaerobic energy metabolism.(IVIS 4)  ''Efficacy'': 60% success rate in an FDA-regulated study.(98 in Furr) ''Potential adverse effects'': adverse effects and death at high doses(98), fever, anorexia, diarrhoea, lethargy, depression and laminitis recorded at lower doses.  Toxic signs usally resolve upon cessation of treatment.(Furr)'''''Caution''': 'administration of nitazoxanide can disrupt the normal microbial flora of the gastrointestinal tract leading to enterocolitis.  Deaths due to enterocolitis have been observed while administering the recommended dose in field studies.''''''(IVIS 4)

Prolonged, off-license treatment is often instigated after 1 month, based on repeated clinical examination.  Even successfully treated cases may remain immunoblot positive for long periods, thus aiming for seronegativity is unrealistic.(Furr)  A lack of response to treatment suggests that the diagnosis should be re-assessed.  Another month's worth of treatment is recommended for partial responders.(Furr)

Prolonged, off-license treatment is often instigated after 1 month, based on repeated clinical examination.  Even successfully treated cases may remain immunoblot positive for long periods, thus aiming for seronegativity is unrealistic.(Furr)  A lack of response to treatment suggests that the diagnosis should be re-assessed.  Another month's worth of treatment is recommended for partial responders.(Furr)

===Ancillary medication===

===Ancillary medication===