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Listeriosis is a bacterial infection caused by [[Listeria species - Overview|''Listeria'' species]]. It affects a wide range of animals and is an important zoonosis.. ''L.monocytogenes'' is found in silage and is the main source of contamination for animals. Soil and the mammalian gastrointestinal tract are natural reservoirs for'' L.monocytogenes'' and if ingested by grazing animals the bacteria will further contaminate the pasture.  The bacteria is very resistant to drying and can survive at a variety of temperatures and PH.

Listeriosis is a bacterial infection caused by [[Listeria species - Overview|''Listeria'' species]]. It affects a wide range of animals and is an important zoonosis.. ''L.monocytogenes'' is found in silage and is the main source of contamination for animals. Soil and the mammalian gastrointestinal tract are natural reservoirs for'' L.monocytogenes'' and if ingested by grazing animals the bacteria will further contaminate the pasture.  The bacteria is very resistant to drying and can survive at a variety of temperatures and PH.

==Signalment==

==Signalment==

==Diagnosis==

==Diagnosis==

Lumbosacral CSF can be collected under local anaesthesia and if the animal is infected will show an increased protein count and mild pleocytosis with large mononuclear cells.

Lumbosacral Cerebrospinal Fluid (CSF) can be collected under local anaesthesia and if the animal is infected will show an increased protein count and mild pleocytosis with large mononuclear cells.

Isolation of ''L. monocytogenes'' provides a definitive diagnosis of listeriosis. The preferred samples for culture are brain, aborted foetus or placenta.

Isolation of ''L. monocytogenes'' provides a definitive diagnosis of listeriosis. The preferred samples for culture are brain, aborted foetus or placenta.

Immunofluorescence can also be used to identify ''L.monocytogenes'' on smears taken from dead or aborted animals.

Immunofluorescence can also be used to identify ''L.monocytogenes'' on smears taken from dead or aborted animals.

==History and Clinical Signs==

==History and Clinical Signs==

The most recognised form of listeriosis in ruminants affects the nervous system causing meningoencephalitis. Animals present depressed, sometimes with a head tilt, facial paralysis, a drooping eyelid and often circling. This can lead to recumbency and death within 24-48 hours.  

The most recognised form of listeriosis in ruminants affects the nervous system causing meningoencephalitis. Animals present depressed, sometimes with a head tilt, facial paralysis, a drooping eyelid, profuse salivation and circling towards the side of the lesion. In terminally affected animals who are recumbent it is common to see unvoluntary running movements. Death can follow clinical signs acutely and is often within 24-48 hours.

In monogastric animals and young ruminants listeriosis causes septicaemia.  

In monogastric animals and young ruminants listeriosis presents differently causing septicaemia which can also be fatal. If animals are infected whilst pregnant this can cause abortion up to 12 days later with a purulent exudate covering the placenta. Animals are affected in the last trimester of gestation having shown no previous clinical signs. Following abortion the animal will often recover normally unless the foetus is retained and metritis will develop.

If animals are infected whilst pregnant this can cause abortion up to 12 days later. Following abortion the animal will often recover normally unless the foetus is retained when septicaemia will follow.

Additionally Listeriosis can also manifest as conjunctivitis when infected silage come in contact with the animals eye, pneumonia, myocarditis and endocarditis.

Listeriosis can also manifest as conjunctivitis when infected silage come in contact with the animals eye, pneumonia, myocarditis and endocarditis.

==Pathology==

==Pathology==

 

==Treatment==

==Treatment==

''L monocytogenes'' is susceptible to a range of antibiotics including penicillin, ceftiofur, erythromycin, and trimethoprim/sulfonamide. In order to achieve high enough levels in the brain high doses are required daily for 1-2 weeks.   

''L monocytogenes'' is susceptible to a range of antibiotics including penicillin, ceftiofur, erythromycin, and trimethoprim/sulfonamide. In order to achieve high enough levels in the brain high doses are required daily for 1-2 weeks.   

In an outbreak, affected animals should be isolated, treated and feeding the silage that the affected animal recieved should be discontinued.

In an outbreak, affected animals should be isolated, treated and silage feeding should be discontinued.

All bedding should be destroyed and buildings should be thoroughly cleaned.  To avoid further outbreaks, ensure animals are fed good quality silage and minimise soil contamination when making silage.  

All bedding should be destroyed and buildings should be thoroughly cleaned.  To avoid further outbreaks, ensure animals are fed good quality silage and minimise soil contamination when making silage.  

For ocular listeriosis Sub-conjuntival antibiotics and corticosteroids can be given.

For ocular listeriosis Sub-conjuntival antibiotics and corticosteroids can be given.

==Prognosis==

==Prognosis==

Recovery depends on rapid diagnosis of the disease. If treated animals can recover however if signs of encepalitis are present treatment is often unsuccessful.

Recovery depends on rapid diagnosis of the disease. If treated, animals can recover however if signs of encepalitis are present treatment is often unsuccessful.

==References==

==References==

Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial

Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial

 

[[Category:Sheep]][[Category:Cattle]]

[[Category:Sheep]][[Category:Cattle]]

[[Category:To_Do_-_Caz]]

[[Category:To_Do_-_Caz]]