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Grass Sickness (view source)

Revision as of 16:03, 23 July 2010

469 bytes removed ,  16:03, 23 July 2010
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==Diagnosis==
 
==Diagnosis==
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Ante-mortm diagnosis of the disease is difficult because changes are confined to the gastro-intestinal tract.
 
===Clinical signs===
 
===Clinical signs===
 
*Depression
 
*Depression
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===Biopsy===
 
===Biopsy===
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A definitive diagnosis is obtained by taking an ileal biopsy, and inspecting the intrinsic myenteric plexus. Degenerative lesions are seen in the autonomic nerve ganglia, 
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A definitive diagnosis is obtained by taking an ileal biopsy and inspecting the intrinsic myenteric plexus. Degenerative lesions and necrosis are seen in the autonomic nerve ganglia and enteric nervous system. 
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*** There is an abrupt change in the [[Large Intestine - Anatomy & Physiology|large intestine]], where no fluid is present.
 
*** There is an abrupt change in the [[Large Intestine - Anatomy & Physiology|large intestine]], where no fluid is present.
 
**** [[Large Intestine - Anatomy & Physiology|large intestine]] has very dry mucoid contents.
 
**** [[Large Intestine - Anatomy & Physiology|large intestine]] has very dry mucoid contents.
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===Pathogenesis===
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** Due to functional obstruction at ileocaecal valve and a degree of paralytic ileus of the [[Small Intestine - Anatomy & Physiology|small intestine]].
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** The exact cause is unknown, but a type of bacterial or fungal toxin which may damage autonomic nervous system ganglia may be involved.
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*** ''[[Clostridium botulinum]]'' is thought to be involved. 
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* A similar condition seen in hares
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** At post mortem look for degenerative changes in coeliaco-mesenteric ganglia -  need to examine histologically. 
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*** Ganglia are peanut sized and found in perirenal fat between adrenal gland and the aorta.
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