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'''Non-suppurative cholangitis'''

'''Non-suppurative cholangitis'''

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==Description==

==Description==

'''Lymphocytic cholangitis''' is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly [[Lymphocytes|lymphocytes]] and [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]].  Bile duct hypertrophy and [[Liver Fibrosis|fibrosis]] are present.  However, lymphocytic cholangitis does not progress to biliary [[Cirrhosis|cirrhosis]].  An immune-mediated aetiology has been postulated but this has not been substantiated to date.  It is rarely associated with [[Pancreatitis - Dog and Cat|pancreatitis]], compared to [[Cholangitis, Neutrophilic]]

'''Lymphocytic cholangitis''' is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly [[Lymphocytes|lymphocytes]] and [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]].  Bile duct hypertrophy and [[Liver Fibrosis|fibrosis]] are present.  However, lymphocytic cholangitis does not progress to biliary [[Cirrhosis|cirrhosis]].  An immune-mediated aetiology has been postulated but this has not been substantiated to date.  It is rarely associated with [[Pancreatitis - Dog and Cat|pancreatitis]], compared to [[Cholangitis, Neutrophilic]]

==Signalment==

==Signalment==

Young to middle-aged cats, 50% are under 4 years old.

Young to middle-aged cats, 50% are under 4 years old.

==Diagnosis==

==Diagnosis==

Vague clinical signs which may include anorexia, depression, weight loss, intermittent [[Stomach and Abomasum Consequences of Gastric Disease - Pathology|vomiting]] and [[Diarrhoea|diarrhoea]], [[Icterus|jaundice]],lymphadenomegaly. Severe illness and pyrexia is less likely compared to [[Cholangitis, Neutrophilic]].   

Vague clinical signs which may include anorexia, depression, weight loss, intermittent [[Stomach and Abomasum Consequences of Gastric Disease - Pathology|vomiting]] and [[Diarrhoea|diarrhoea]], [[Icterus|jaundice]],lymphadenomegaly. Severe illness and pyrexia is less likely compared to [[Cholangitis, Neutrophilic]].   

Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.

Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.

===Laboratory Tests===

===Laboratory Tests===

====Biochemistry====

====Biochemistry====

Increased alkaline phosphatase (ALP), alanine aminotransferase (ALT), Hyperbilirubinaemia and Hyperglobulinaemia.

Increased alkaline phosphatase (ALP), alanine aminotransferase (ALT), Hyperbilirubinaemia and Hyperglobulinaemia.

===Diagnostic Imaging===

===Diagnostic Imaging===

==Prognosis==

==Prognosis==

Poor due to the waxing and waning feature of this disease.  In cats, this disease does not usually progress to end-stage cirrhosis and therefore it does not usually result in death, which is in contrast to dogs.

Poor due to the waxing and waning feature of this disease.  In cats, this disease does not usually progress to end-stage cirrhosis and therefore it does not usually result in death, which is in contrast to dogs.

==References==

==References==

[[Category:Gall_Bladder_and_Tract_-_Pathology]][[Category:To_Do_-_Caz]]

[[Category:Gall_Bladder_and_Tract_-_Pathology]][[Category:To_Do_-_Caz]]

[[Category:Cat]][[Category:Dog]]

[[Category:Cat]][[Category:Dog]]

[[Category:To_Do_-_Review]]

[[Category:Expert_Review]]