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| | ===Pathology=== | | ===Pathology=== |
| − | 3 major features:
| + | The organism gains entry to the soft tissues of the head causing an inflammatory reaction, the connective tissue proliferates and is followed by infiltration of leukocytes which results in a walled off granuloma. The granuloma invades the bones of the head, in particular the mandible, and continues to grow in size. |
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| − | #Inflammatory removal of bone. As cortex of bone is pushed out by central inflammation produces thinning of bone cortex with proliferation of new periosteal bone. The centre of the [[Skull and Facial Muscles - Anatomy & Physiology#Mandible (mandibula)|mandible]] is eroded forming a honeycomb-like bone. Eventually will erode through bone producing [[Granuloma|granulomatous]] lesion on bottom of [[Skull and Facial Muscles - Anatomy & Physiology#Mandible (mandibula)|mandible]] and eventually eroding through skin.
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| − | #Granuloma with micro abscess's in centre with greenish / yellow granules in middle of pus. These granules known as "sulphur bodies". Sulphur body is a colony of tangled mass of Actinomyces filaments. This is surrounded by [[Neutrophils|neutrophils]] and [[Macrophages|macrophages]] forming a pyogenic granuloma.
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| − | #Masses of fibrous tissue surround the granuloma and fill the spaces where bone has been destroyed
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| | ==Treatment== | | ==Treatment== |