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| Simple serology is impossible as most cats will have antibody to FECoV. | | Simple serology is impossible as most cats will have antibody to FECoV. |
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− | However, 4 indicators can be used to cross reference: | + | However, 4 indicators can be used for diagnosis: |
− | *High FECoV Ab titres | + | *High FECoV Antibody titres |
| *Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP) | | *Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP) |
| *High levels of glycoprotein alpha 1-acid glycoprotein (AGP) | | *High levels of glycoprotein alpha 1-acid glycoprotein (AGP) |
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| Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea. | | Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea. |
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− | ====Epidemiology====
| + | |
− | *FECoV is '''endemic worldwide''', with the majority of cats showing a subclinical seroconversion
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− | *'''Orofecal, aerosol, and contact''' transmission
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− | *Particular concern for '''catteries''' and homes with '''multiple cats'''
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− | *
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| ==Pathology== | | ==Pathology== |
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| ==Control== | | ==Control== |
− | Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK | + | Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK. Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity and it cannot protect cats already infected with FECoV. |
− | **Temperature-sensitive mutant
| + | Antibody tests are available to certify FECoV-free cat houses. |
− | **Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity
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− | **Cannot protect cats already infected with FECoV
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− | **Kittens must be isolated until old enough to vaccinate at 16 weeks
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− | Antibody tests are available to certify "FECoV-free" cat houses | |
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