Changes

The disease usually affects weanlings '''6-10 weeks old''' when maternal antibodies wane but it can affect pigs of any age, particularly naive pigs introduced into a herd or through exposure to a strain to which there is little immunity.

The disease usually affects weanlings '''6-10 weeks old''' when maternal antibodies wane but it can affect pigs of any age, particularly naive pigs introduced into a herd or through exposure to a strain to which there is little immunity.

The disease occurs '''worldwide''', it is endemic in most herds but incidence of clinical disease in the UK is sporadic.Increased prevelance hgas been associated with [[Porcine Reproductive and Respiratory Syndrome|PRRS]], [[Porcine Circoviruses|Circovirus]] and [[Swine Influenza|Swine Influenza.]]  

The disease occurs '''worldwide''', it is endemic in most herds but incidence of clinical disease in the UK is sporadic due to widespread acquired resistance. Increased prevelance hgas been associated with [[Porcine Reproductive and Respiratory Syndrome|PRRS]], [[Porcine Circoviruses|Circovirus]] and [[Swine Influenza|Swine Influenza.]]  

 

==Diagnosis==  

==Diagnosis==

 

===Clinical signs===

===Clinical signs===

*Pyrexia

*Pyrexia

*Sudden death

*Sudden death

Clinical signs develop rapidly, the disease is often fatal within 2-5 days. The skin becomes discoloured, turning red to blue before death.  

Clinical signs develop rapidly, the disease is often fatal within 2-5 days. The skin becomes discoloured, turning red to blue before death. Expressed lesions vary between animals - meningitis is most consistent, arthritis in 20% of cases

 

Survivors or those affected by the chronic form of the disease become lame with arthritis, develop congestive heart failure, pericarditis or intestinal obstruction due to formation of adhesions.   

Survivors or those affected by the chronic form of the disease become lame with arthritis, develop congestive heart failure, pericarditis or intestinal obstruction due to formation of adhesions.   

**Also causes suppurative [[Respiratory Bacterial Infections - Pathology#Glasser's disease|bronchopneumonia, pleuritis]],  [[Joints Inflammatory - Pathology#In Pigs|polyarthritis]] (also ''H. suis)

**Also causes suppurative [[Respiratory Bacterial Infections - Pathology#Glasser's disease|bronchopneumonia, pleuritis]],  [[Joints Inflammatory - Pathology#In Pigs|polyarthritis]] (also ''H. suis)

**Fever, general malaise, repsiratory and abdominal signs, lameness, paralysis or convulsions. Expressed lesions vary between animals - meningitis is most consistent, arthritis in 20% of cases

**Fever, general malaise, repsiratory and abdominal signs, lameness, paralysis or convulsions.  

 

 

**Chronic arthritis, meningitis and intestinal obstruction due to adhesions in some surviving pigs

**Chronic arthritis, meningitis and intestinal obstruction due to adhesions in some surviving pigs

**Due to transport, environmental stresses, dietary and managemental factors

**Due to transport, environmental stresses, dietary and managemental factors