*Usually the primary pathogen is a virus, secondary pathogens are bacteria and mycoplasmas
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*Pathogens:
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All transmitted by aerosol and direct contact
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**[[:Category:Mycoplasmas|''Mycoplasmas'']]
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***Mycoplasmal [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchitis]] and [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]] of calves is an important component of the syndrome of enzootic pneumonia
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***On its own causes Mycoplasmal ("Cuffing") pneumonia responsible for [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchitis and bronchiolitis]] and [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|bronchointerstitial pneumonia]]
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***It is thought to pick up host antigens in order to prevent recognition by the body defences as foreign
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***In uncomplicated mycoplasma infection, the lesions are generally mild and consist of patchy red/purple areas of [[Lungs Ventilation - Pathology#Atelectasis|atelectasis]] in the '''cranio-ventral lung lobes'''
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***More confluent areas can develop with an underlying bronchointestitial pneumonia and resulting atelectasis
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***''M. bovis''
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****Most pathogenic
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****Widespread lymphofollicular accumulations which contain germinal centres develop more slowly
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****These lesions can result in narrowing of the bronchiolar lumina - this is the classical lesion of '''‘cuffing pneumonia’'''