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#REDIRECT[[Streptococcus equi subsp. equi]]
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Caused by ''[[Streptococcus equi subsp. equi]]''
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*Epidemiology
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**[[Respiratory Bacterial Infections - Pathology#Strangles|Strangles]] is a highly infectious disease of horses caused by ''Streptococcus equi'' subsp. ''equi''
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**[[Respiratory Bacterial Infections - Pathology#In Horses|upper respiratory tract disease of horses]] with fever and abscessation of regional lymph nodes
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**Cause rhinitis, [[Nasopharynx Inflammatory - Pathology|pharyngitis]], lymphadenitis and [[Muscles Inflammatory - Pathology#Abscesses|myositis]]
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**Outbreaks in groups of young horses
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**Transmitted via purulent exudate discharging from upper respiratory tract or from lymph nodes
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**Chronic, carrier state can occur with bacteria im the guttural pouch
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**A mild, atypical form can occur
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**''S. equi'' shed for 4 weeks beyond clinical resolution
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*Clinical signs
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**Incubation period 3 to 6 days
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**Fever, depression, anorexia
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**Purulent nasal discharge
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**Swollen, painful regional lymph nodes, especially submandibular
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**Abscessation and rupture of lymph nodes
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**Guttural pouch empyema
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**100% morbidity; 5% mortality
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**Death can occur from pneumonia, breathing difficulties from swollen lymph nodes or [[Muscles Degenerative - Pathology#Ischaemia|purpura haemorrhagica]](an immune-mediated disease)
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**Bastard strangle may occasionally occur, with abscessaation in many organs of the body
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**''S. equi'' may be involved in [[Bacterial skin infections - Pathology#Systemic bacterial infections|cutaneous lesions]]
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*Diagnosis
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**Clinical signs and history
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**Mucoid colonies with beta-haemolysis
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**Sugar fermentation allows differentiation of ''S. equi'' from ''S. zooepidemicus'' and ''S. equisimilis''
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**PCR to detect asymptomatic carriers
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*Treatment and control
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**Penicillin administration to in-contact animals
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**Isolation of affected animals
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**Quarantne in-coming animals
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**Avoid overcrowding and mixing different age groups
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**Disinfection of equipment
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*Gross pathology
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**Initial bilateral nasal discharge, serous becoming purulent
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**Catarrhal conjunctivitis may be present
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*Less frequently, complications can occur as follows :
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**Purulent inflammation may extent to [[Guttural Pouches Inflammatory - Pathology|guttural pouches]] or [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|lungs]], [[Paranasal Sinuses Inflammatory - Pathology#Infectious causes of sinusitis|sinusitis]]
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**Bacteraemia with metastatic abscesses - most often to the mesenteric and mediastinal lymph nodes, less frequently, other organs such as [[Liver - Anatomy & Physiology|liver]], kidney and brain can be involved - '''Bastard strangles'''
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**Retropharyngeal abscesses can rupture onto the skin of neck or into the [[Guttural Pouches Inflammatory - Pathology|guttural pouch]] resulting in '''guttural pouch empyema or chondroid formation''' - carrier state
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**[[Muscles Degenerative - Pathology#Ischaemia|'''Purpura haemorrhagica''']]: an acute vasculitis causing urticaria and extensive oedema of ventrum, head and distal limbs
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**[[Larynx Degenerative - Pathology#Laryngeal hemiplegia|Laryngeal hemiplegia]] due to enlarged retropharyngeal lymph nodes
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**Compression of cranial nerves
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*Interview with Professors Josh Slater and Ken Smith providing an interesting insight into the pathogenesis, prevalence and possible prevention of ''Streptococcus equi'' infections in horses - listen to [http://www.rvc.ac.uk/Review/Podcasts/RVC_Podcast_12.m4a Strangles podcast]
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[[Category:Respiratory_Bacterial_Infections]]
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[[Category:Respiratory_Disorders_-_Horse]]
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[[Category:To_Do_-_Respiratory]]
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