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| ==Treatment== | | ==Treatment== |
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− | | + | ===Treatment problems=== |
− | The prevalence of gastric ulcers in horses remains high regardless of the common use of antiulcer treatments. This has been attributed to the expense of recommended products encouraging subtherapeutic and curtailed dosing schedules(Orsini et al 2003 in Nadeau 2009). Omeprazole and ranitidine must be administered for at least 28 days for adequate ulcer healing.(Nadeau 2009) | + | The prevalence of gastric ulcers in horses remains high regardless of the common use of antiulcer treatments. This has been attributed to the expense of recommended products encouraging subtherapeutic and curtailed dosing schedules(Orsini et al 2003 in Nadeau 2009). Omeprazole and ranitidine must be administered for at least 28 days for adequate ulcer healing.(Nadeau 2009) In the USA, compounded omeprazole from bulk powders are used as a cheaper substitute for the FDA approved products. However, these formulations lack efficacy and are not regulated (Nieto et al. 2002; Merritt et al. 2003; Orsini et al. 2003).(Nadeau 2009) |
| + | A considerable challenge lies in the management of abdominal pain associated with EGUS, since the commonly used NSAIDs for pain control may worsen and even induce further ulcerative lesions.<ref>Videla, R, Andrews, F.M (2009) New perspectives in equine gastric ulcer syndrome.''Vet Clin North Am Equine Pract'', 25(2):283-301.</ref> Another challenge is the horse that cannot take oral medication. However, Andrews and colleagues (2006) have demonstrated the efficacy of an omeprazole powder, adminstered IV in sterile water, which signifcantly increased the pH of equine gastric contents and may be useful in problem horses. |
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− | Omeprazole has been shown to be more effective than ranitidine in treatment of EGUS in horses..
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− | Recently, an omeprazole powder (0.5 mg/kg bwt, i.v.) was given to horses daily for 5 days (Andrews et al. 2006). In that study, gastric juice pH significantly increased 1 h after the first injection and remained increased 24 h after the 4th injection and after the 5th daily injection. Due to the variability of gastric juice pH in the horses, the authors recommended the administration of a loading dose of 1 mg/kg bwt, i.v., then a maintenance dose (0.5 mg/kg bwt, i.v.) daily for treatment of gastric ulcers in horses that are not able to be given the oral paste formulation.
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− | In the USA, compounded omeprazole from bulk powders are used as a substitute for the FDA approved formulation. However, these compounds are not regulated and many lack efficacy intreatment of gastric ulcers (Nieto et al. 2002; Merritt et al. 2003; Orsini et al. 2003). These compounds are used because of the expense of approved products.(Nadeau 2009)
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− | Vet Clin North Am Equine Pract. 2009 Aug;25(2):283-301.
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− | New perspectives in equine gastric ulcer syndrome.
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− | Videla R, Andrews FM.
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− | Management of horses with abdominal pain caused by gastric ulcers is especially difficult, because non-steroidal anti-inflammatory agents, typically used to control abdominal pain, may exacerbate this condition.
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| Acid suppression | | Acid suppression |