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Gastric Ulceration - Horse (view source)

Revision as of 13:30, 30 July 2010

267 bytes removed ,  13:30, 30 July 2010
→‎Gastric prokinetics
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In cases of gastrooesophageal reflux, duodenal disease and delayed gastric emptying without a serious physical obstruction to gastric outflow, gastric prokinetics might be considered.(Sanchez)  Such compounds include bethanechol, metaclopramide, erythromycin and cisapride which have been shown to hasten gastric empyting in adult horses.(EGUC)  To date only the parasympathomimetic agent bethanechol has been used as an adjunct for EGUS and cholinergic side effects are possible.  Cisapride has been withdrawn from the US and UK markets over concern about its potential to cause adverse cardiac effects in man.(Sanchez)
 
In cases of gastrooesophageal reflux, duodenal disease and delayed gastric emptying without a serious physical obstruction to gastric outflow, gastric prokinetics might be considered.(Sanchez)  Such compounds include bethanechol, metaclopramide, erythromycin and cisapride which have been shown to hasten gastric empyting in adult horses.(EGUC)  To date only the parasympathomimetic agent bethanechol has been used as an adjunct for EGUS and cholinergic side effects are possible.  Cisapride has been withdrawn from the US and UK markets over concern about its potential to cause adverse cardiac effects in man.(Sanchez)
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Proton pump inhibitors: only omeprazole (Gastroguard) is licensed for horses.  Given PO once daily (4mg/kg) for 3-4 wks, most effective drug at controlling HCl secretion (decreases basal and stimulated release).  Expensive and not absorbed in foals with diarrhoea
      
===Treatment problems===
 
===Treatment problems===
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