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→Haematological Disease
*'''[[Arrhythmias Overview|Arrhthymias]]'''
*'''[[Arrhythmias Overview|Arrhthymias]]'''
====Haematological Disease====
====Haematological Disease====
*'''Thrombocytopathia''' - The reduction in platelet function occur due to multiple alterations in normal [[Thrombocyte|thrombocyte]] metabolism.
*'''Thrombocytopathia''' - The reduction in platelet function occur due to multiple alterations in normal [[Thrombocytes|thrombocyte]] metabolism.
*'''Anaemia''' - This occurs because the diseased kidenys produce less erythropoietin than normal and the uraemic toxins (especially PTH) decrease the lifespan of existing red blood cells. Erythrocytes may also be damaged as they pass along inflamed vessel walls, a form of microangiopathic haemolysis. Chronic gastro-intestinal haemorrhage may also result in iron deficiency.
*'''Anaemia''' - This occurs because the diseased kidenys produce less erythropoietin than normal and the uraemic toxins (especially PTH) decrease the lifespan of existing red blood cells. Erythrocytes may also be damaged as they pass along inflamed vessel walls, a form of microangiopathic haemolysis. Chronic gastro-intestinal haemorrhage may also result in iron deficiency.
====Neuromuscular Disease====
====Neuromuscular Disease====
*'''Neurological disease''' - The presence of extremely high concentrations of urea and creatinine may induce '''reduced conciousness''' or '''uraemic seizures''' and this is usually a terminal event. PTH has also been implicated in the development of uraemic encephalopathy, possibly due to alterations in calcium pumps. Animals may enter a so-called '''twitch-convulsive''' state where they suffer concurrent tremors, myoclonus and seizures. Peripheral neuropathies may contribute to the reduced hindlimb function that is commonly ascribed to hypokalaemic myopathy.
*'''Neurological disease''' - The presence of extremely high concentrations of urea and creatinine may induce '''reduced conciousness''' or '''uraemic seizures''' and this is usually a terminal event. PTH has also been implicated in the development of uraemic encephalopathy, possibly due to alterations in calcium pumps. Animals may enter a so-called '''twitch-convulsive''' state where they suffer concurrent tremors, myoclonus and seizures. Peripheral neuropathies may contribute to the reduced hindlimb function that is commonly ascribed to hypokalaemic myopathy.