Changes

Mammary involvement is now rarely seen, the uterine form is also uncommon but may reult in abortion.

Mammary involvement is now rarely seen; the uterine form is also uncommon but may result in abortion.

===Laboratory Tests===

===Laboratory Tests===

An ELISA test has been developed but is not widely used. The gamma interferon test can also be used for diagnosis of the condtion.

An ELISA test has been developed but is not widely used. The gamma interferon test can also be used for diagnosis of the condition.

===Pathology===

===Pathology===

Findings at post mortem depend on the route of entry of the organism, whether it became generalised or not and the stage of the disease.  

Findings at post mortem depend on the route of entry of the organism, whether it became generalised or not and the stage of the disease.  

One or more lymph nodes will display the chacteristic granulomatous tubercules. In the respiratory form the mediastinal and bronchial lymph nodes are affected, with lesions in the lungs.  

One or more lymph nodes will display the characteristic granulomatous tubercles. In the respiratory form the mediastinal and bronchial lymph nodes are affected, with lesions in the lungs.  

If the mycobacteria disseminated from the primary complex then lymph nodes in other regions will also be affected and there will be multiple small foci of infection on other organs.  

If the mycobacteria disseminated from the primary complex then lymph nodes in other regions will also be affected and there will be multiple small foci of infection on other organs.  

Treatment is not usually an option due to the chronic nature of the disease, zoonotic potential and test and slaughter policy.  

Treatment is not usually an option due to the chronic nature of the disease, zoonotic potential and test and slaughter policy.  

Control in many countries is centered on tuberculin testing with slaughter of reactors and movement restrictions to the premises.  

Control in many countries is centred on tuberculin testing with slaughter of reactors and movement restrictions to the premises.  

Research work continues into the use of vacination, or a cull strategy for the associated wildlife populations.  

Research work continues into the use of vaccination, or a cull strategy for the associated wildlife populations.  

==Prognosis==

==Prognosis==

Poor.

Poor.

 

==References==

==References==

*Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) '''Bovine Medicine''' (Second edition), ''Blackwell Publishing''

*Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) '''Bovine Medicine''' (Second edition), ''Blackwell Publishing''