1,406
edits
Changes
→Intrinsic ulcerogenic factorsNadeau, J.A, Andrews, F.M (2009) Science: Overviews Equine gastric ulcer syndrome: The continuing conundrum. Equine Vet J, 41(7):611-615.
*'''Hydrochloric acid''' compromises the outer cell barrier of the squamous epithelium. It then diffuses into the cells of the ''stratum spinosum'', inhibiting cellular sodium transport and causing cell swelling, necrosis and eventual ulceration.<ref>Nadeau, J.A, Andrews, F.M, Patton, C.S, Argenzio, R.A, Mathew, A.G, Saxton, A.M (2003) Effects of hydrochloric, acetic, butyric, and proprionic acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. ''Am J Vet Res'',64:404-412.</ref><ref>Nadeau, J.A, Andrews, F.M, Patton, C.S, Argenzio, R.A, Mathew, A.G, Saxton, A.M (2003) Effects of hydrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. ''Am J Vet Res'', 64:413-417.</ref>
*'''Hydrochloric acid''' compromises the outer cell barrier of the squamous epithelium. It then diffuses into the cells of the ''stratum spinosum'', inhibiting cellular sodium transport and causing cell swelling, necrosis and eventual ulceration.<ref>Nadeau, J.A, Andrews, F.M, Patton, C.S, Argenzio, R.A, Mathew, A.G, Saxton, A.M (2003) Effects of hydrochloric, acetic, butyric, and proprionic acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. ''Am J Vet Res'',64:404-412.</ref><ref>Nadeau, J.A, Andrews, F.M, Patton, C.S, Argenzio, R.A, Mathew, A.G, Saxton, A.M (2003) Effects of hydrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. ''Am J Vet Res'', 64:413-417.</ref>
*'''VFAs''': acetic, propionic, butyric and valeric acids are lipid soluble, which enables them to readily diffuse into the stratum spinosum and immediately cause the damage as described above.
*'''VFAs''': acetic, propionic, butyric and valeric acids are lipid soluble, which enables them to readily diffuse into the ''stratum spinosum'' and immediately cause the damage as described above.
*'''Lactic acid''': has been shown to increase the permeability of the squamous mucosa.<ref>Andrews, F.M, Buchanan, B.R, Elliott, S.B, Al Jassim, R.A.M, McGowan, C.M, Saxton, A.M (2008) ''In vitro'' effects of hydrochloric and lactic acids on bioelectric properties of equine gastric squamous mucosa. ''Equine Vet J'', 40:301-305.</ref>
*'''Lactic acid''': has been shown to increase the permeability of the squamous mucosa.<ref>Andrews, F.M, Buchanan, B.R, Elliott, S.B, Al Jassim, R.A.M, McGowan, C.M, Saxton, A.M (2008) ''In vitro'' effects of hydrochloric and lactic acids on bioelectric properties of equine gastric squamous mucosa. ''Equine Vet J'', 40:301-305.</ref>