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| | ==Pathology== | | ==Pathology== |
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| − | Inflammatory bowel disease will result in malabsorption and in many cases, chronic diarrhoea.
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| − | The small and/or [[Large Intestine - Anatomy & Physiology|large intestine]]s are affected.
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| − | The site determines whether diarrhoea is present.
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| − | Additionally, can get extraintestinal abnormalities including cholangiohepatitis, nephritis, pancreatitis, polyarthropathy and thrombocytopenia (uncommon).
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| | The term "inflammatory bowel disease" covers several conditions characterised by the major inflammatory cell(s) present. All have some common features: thickening of the mucosa, villus atrophy in advanced disease and significant inflammatory infiltrate in the mucosa and sometimes deeper layers. | | The term "inflammatory bowel disease" covers several conditions characterised by the major inflammatory cell(s) present. All have some common features: thickening of the mucosa, villus atrophy in advanced disease and significant inflammatory infiltrate in the mucosa and sometimes deeper layers. |
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| − | ==Granulomatous enteritis==
| + | Increased numbers of plasma cells, lymphocytes, eosinophils, and neutrophils in the lamina propria are seen in IBD. |
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| − | Is seen mainly in the dog but also in the cat and horse. It is idiopathic but causes granulomatous inflammation.
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| − | Macrophages, giant cells, [[Neutrophils|neutrophils]], eosinophils, lymphocytes and plasma cells are present.
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| − | ==Idiopathic colitis==
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| − | Affects the dog.
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| − | ==Histiocytic Ulcerative Colitis==
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| − | Occurs in the dog and cat. In the dog, animals less than two years old are most likely to be affected.
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| − | *** Particularly the boxer and French bulldog.
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| − | * Produces soft faeces containing mucous and blood.
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| − | ===Pathology===
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| − | Produces raised ulcerative nodules in the colon, due to a macrophage infiltration of the mucosa and submucosa. Macrophages are filled with PAS positive material. Electron microscopy demonstrates macrophages to be filled with [[Escherichia coli|''E.coli'']] antigen. There will also be an accompanying lymphadenopathy.
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