Changes

==Introduction==

==Introduction==

CAV1 was first isolated by Carbasso in 1954 in from a dog suffering from acute hepatitis and was identical to the virus isolated by Rubarth in 1947. For that reason, CAV1 was originally known as ICH (infectious canine hepatitis) virus. Infection was subsequently shown to be a common occurence in young dogs across the world. In Britain, 82% of dogs were found to have neutralising antibody titres by the time they were 9 months old (Ablett and Baker, 1960). This high incidence of infection is not matched by a similar incidence of clinical hepatitis, and it si now known that many infections are subclinical and that the virus is also responsible for other conditions, e.g. encephalopathy, ocular disease, neonatal disease, chronic hepatitis, and interstitial nephritis. In several countries, the virus has been isolated from throat swabs or lungs from dogs with respiratory disease, and in Britain CAV-1 is thought to be of importane in kennel cough (infectious tracheobronchitis).

 

CAV1 was first isolated by Carbasso in 1954 ¹from a case of acute hepatitis in the dog. This virus found to be identical to the virus isolated in 1947 by Rubarth² from a dog showing acute liver lesions, and so CAV1 was originally known as Infectious Canine Hepatitis (ICH) virus. Subsequently, CAV1 infection was shown to be common in young dogs worldwide, with 82% of British dogs displaying neutralising antibody titres by nine months of age³. It has also since been demonstrated that CAV1 has a role in diseases other than infectious canine hepatitis, and CAV1 infection has been the subject of many studies.  

 

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==Disease==

==Disease==

Clinical signs include depression, fever, vomiting, diarrhea, and  discharges from the nose and eyes. Because of a tendency to bleed,  hematomas may be seen in the mouth.

Clinical signs include depression, fever, vomiting, diarrhea, and  discharges from the nose and eyes. Because of a tendency to bleed,  hematomas may be seen in the mouth.