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1,725 bytes removed ,  16:09, 6 August 2010
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==Treatment==
 
==Treatment==
 
==Prognosis==
 
==Prognosis==
====Antigenicity====
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*Isolates vary in virulence
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*Some antigenic variation
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*Best defined by monoclonal antibodies, but no serotypes
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====Hosts====
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*Pigs
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*Wild boar
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====Pathogenesis====
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*Virus enters oropharynx and replicates in palatine tonsil
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*Viremia 2-6 days post-infection
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Two types of strain:
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#Low Virulence:
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#*Transplacental transmission causes abortion, cerebellar hypoplasia, or growth retardation
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#*If piglets are born, they are carriers
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#High Virulence:
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#*Leukopenia
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#*Thrombocytopenia
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#*Generalized '''vasculitis'''
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#*'''Hemorrhage''' of lymph nodes, spleen, bladder, larynx, and skin
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#*Vasculitis in CNS causes tremors, incoordination and convulsions
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Chronic disease:
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*Infarction causes '''button ulcers''' over Peyer's Patches
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====Epidemiology====
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*Recovered animals are immune
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*'''Highly contagious'''
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*Transfer via '''contact''', '''aerosol''', or '''fomites'''
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*Swine fever was once endemic worldwide but has now been '''eradicated''' from UK, Australia, NZ, USA, and Denmark following vaccination schemes
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====Diagnosis====
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*'''Immunofluorescence''' of tissues for virus isolation
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*DD: Porcine circovirus 2, African swine fever, or bacterial septicemia
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====Control====
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*'''NOTIFIABLE''' disease
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*'''Vaccination''' (live attenuated) in endemic countries:
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**Parts of EU are using vaccinated bait to control spread in wild boar population
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**Vaccination does not curtail spread: marker vaccine needed to distinguish virus exposure from vaccine-induced antibody
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* ''Pestivirus'' invades vascular endothelium and macrophages
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** Leads to infarcted lesions
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** In spleen
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** "Button ulcers" in colon and caecum.
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*** Ulcers are seen as discrete circular areas of haemorrhage and necrosis with dry, yellow centres
      
[[Category:Pestiviruses]][[Category:Pig]]
 
[[Category:Pestiviruses]][[Category:Pig]]
 
[[Category:Enteritis,_Viral]][[Category:Enteritis,_Ulcerative]]
 
[[Category:Enteritis,_Viral]][[Category:Enteritis,_Ulcerative]]
 
[[Category:To_Do_-_Lizzie]]
 
[[Category:To_Do_-_Lizzie]]
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