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In the acute form, animals are almost always pyrexic. In piglets under 12 weeks old the fever may exceed 40°, but in adults temperatures may be no higher than 39.5°. Lethargy, conjunctivitis, lymphomegaly may be seen, as well as respiratory signs and diarrhoea. Neurological signs such as gait abnormalities, incoordination and convulsions are also common. The most telling sign of classical swine fever is haemorrhage of the skin. These arise in the second or third week post-infection on the ear, tail, abdomen and medial aspect of the limbs and persist until death.
 
In the acute form, animals are almost always pyrexic. In piglets under 12 weeks old the fever may exceed 40°, but in adults temperatures may be no higher than 39.5°. Lethargy, conjunctivitis, lymphomegaly may be seen, as well as respiratory signs and diarrhoea. Neurological signs such as gait abnormalities, incoordination and convulsions are also common. The most telling sign of classical swine fever is haemorrhage of the skin. These arise in the second or third week post-infection on the ear, tail, abdomen and medial aspect of the limbs and persist until death.
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The virus is shed from the infected animal by saliva,
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urine and faeces (Depner et al., 1994; Laevens et al.,
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1999).
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Pathological changes visible on post mortem examination
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are observed most often in lymph nodes,
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spleen and kidneys. The lymph nodes become swollen,
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oedematous and haemorrhagic (Fig. 2). Haemorrhages
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of the kidney may vary in size from petechiae
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to ecchymotic haemorrhages. Petechiae can also be
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observed in the urinary bladder, larynx, epiglottis and
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heart, and may be widespread over the serosae of the
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abdomen and chest. A non-purulent encephalitis is
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often present (Gruber et al., 1995).
   
CSF virus causes severe leukopenia and immunosuppression,
 
CSF virus causes severe leukopenia and immunosuppression,
 
which often leads to secondary
 
which often leads to secondary
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