Changes

===Clinical Signs===

===Clinical Signs===

Signs may be peracute or acute in onset. In acute cases, the key clinical findings are vomiting, abdominal pain, anorexia, diarrhoea and pyrexia. Some cases may also show signs of a bleeding disorder. However, there are many different features that clinical examination could possibly reveal. These might include:  

Signs may be peracute or acute in onset. Peracute cases are pyrexic and show CNS signs, vascular collapse and disseminated intravascular coagulation, and die within hours. In acute cases, the key clinical findings tend to be pyrexia, vomiting, diarrhoea, abdominal pain and anorexia, and some cases also show signs of a bleeding disorder. However, there are many different features that clinical examination could possibly reveal, and these could include:  

* Abdominal distension and/or pain

* Abdominal distension and/or pain

* Hepatomegaly

* Hepatomegaly

* Pharyngitis or tonsilar enlargement

* Pharyngitis or tonsilar enlargement

* CNS signs such as depression, disorientation and seizures.

* CNS signs such as depression, disorientation and seizures.

In the late stage of disease, 20% of cases develop corneal oedema and anterior uveitis ("blue eye") 4-6 days post-infection. In most cases, these ocular signs resolve within 21 days but some may progress to corneal ulceration or glaucoma.

Clinical signs generally persist for five to seven days before the animal's condition improves. During the recovery phase, 20% of cases develop corneal oedema and anterior uveitis ("blue eye"). In peracute cases, death rapidly follows the onset of clinical signs.

 

===Laboratory Tests===

===Laboratory Tests===