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Created page with "===Disease associated with platelet abnormalities=== ====Primary Thrombocytopenic Disease==== * The aetiology of primary thrombocytopenic disease is often uncertain. ** It is ..."
===Disease associated with platelet abnormalities===
====Primary Thrombocytopenic Disease====
* The aetiology of primary thrombocytopenic disease is often uncertain.
** It is therefore also known as idiopathic thrombocytopenia.
** The cause may be automimmune.
* Although the [[Bone Marrow - Anatomy & Physiology|bone marrow]] contains adequate normal megakaryocytes, there is a reduced peripheral blood thrombocyte count.
* Usually seen in young animals.
====Secondary Thrombocytopenic Disease====
* Secondary thrombocyopaenic disease is fairly common in adult and older domestic animals.
* Associated with diseases which cause [[Bone Marrow - Anatomy & Physiology|bone marrow]] depression.
* The [[Bone Marrow - Anatomy & Physiology|bone marrow]] is depleted or devoid of megakaryocytes, and there is a nil or markedly reduced peripheral blood thrombocyte count.
* Secondary thrombocyopenic disease is seen in the following conditions:
*# Severe viral infections.
*#* For examople, ICH, feline panleucopenia, [[Bovine Viral Diarrhoea Virus|mucosal disease]], [[Classical Swine Fever|swine fever]].
*# Severe protozoal infections.
*#* For example, in the UK, Haemobartonella may be a cause.
*# Plant intoxications.
*#* For example, bracken, kale, or ragwort poisoning.
*# Drug-induced conditions.
*#* High doses of oestrogens and salicylate.
*#* Prolonged use of phenyl butazone.
*# [[Bone Marrow - Anatomy & Physiology|bone marrow]] neoplasia.
*#* For example, lymphosarcoma or myeloid leukaemia.
*# Radiation.
*#* May cause damage to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] if it is severe and generalised.
*# Other miscellaneous causes.
*#* Severe bacterial infections.
*#** For example, [[:Category:Staphylococcus species|''Staphylococci'']], and those Gram -ve bacteria producing endotoxins (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas'']] or [[Salmonella|''Salmonella'']] spp.).
*#* [[Liver - Anatomy & Physiology|Liver]] disease.
====Thrombocytopathia====
* A rare inherited condition.
* Recorded in the dog.
* Characterised by defective thrombocyte formation.
** Poor adhesiveness.
** Poor aggregations.
** Poor platelet factor release.
[[Category:Haemorrhagic Diseases]]
====Primary Thrombocytopenic Disease====
* The aetiology of primary thrombocytopenic disease is often uncertain.
** It is therefore also known as idiopathic thrombocytopenia.
** The cause may be automimmune.
* Although the [[Bone Marrow - Anatomy & Physiology|bone marrow]] contains adequate normal megakaryocytes, there is a reduced peripheral blood thrombocyte count.
* Usually seen in young animals.
====Secondary Thrombocytopenic Disease====
* Secondary thrombocyopaenic disease is fairly common in adult and older domestic animals.
* Associated with diseases which cause [[Bone Marrow - Anatomy & Physiology|bone marrow]] depression.
* The [[Bone Marrow - Anatomy & Physiology|bone marrow]] is depleted or devoid of megakaryocytes, and there is a nil or markedly reduced peripheral blood thrombocyte count.
* Secondary thrombocyopenic disease is seen in the following conditions:
*# Severe viral infections.
*#* For examople, ICH, feline panleucopenia, [[Bovine Viral Diarrhoea Virus|mucosal disease]], [[Classical Swine Fever|swine fever]].
*# Severe protozoal infections.
*#* For example, in the UK, Haemobartonella may be a cause.
*# Plant intoxications.
*#* For example, bracken, kale, or ragwort poisoning.
*# Drug-induced conditions.
*#* High doses of oestrogens and salicylate.
*#* Prolonged use of phenyl butazone.
*# [[Bone Marrow - Anatomy & Physiology|bone marrow]] neoplasia.
*#* For example, lymphosarcoma or myeloid leukaemia.
*# Radiation.
*#* May cause damage to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] if it is severe and generalised.
*# Other miscellaneous causes.
*#* Severe bacterial infections.
*#** For example, [[:Category:Staphylococcus species|''Staphylococci'']], and those Gram -ve bacteria producing endotoxins (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas'']] or [[Salmonella|''Salmonella'']] spp.).
*#* [[Liver - Anatomy & Physiology|Liver]] disease.
====Thrombocytopathia====
* A rare inherited condition.
* Recorded in the dog.
* Characterised by defective thrombocyte formation.
** Poor adhesiveness.
** Poor aggregations.
** Poor platelet factor release.
[[Category:Haemorrhagic Diseases]]