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→Interpretation of Encephalitozoon antibody tests (Keeble 2007)
==Interpretation of Encephalitozoon antibody tests (Keeble 2007)==
==Interpretation of Encephalitozoon antibody tests (Keeble 2007)==
Single positive result in healthy rabbit
===Single positive result in healthy rabbit===
*Recent infection prior to development of clinical signs
*Recent infection prior to development of clinical signs
*Chronically infected with no clinical signs
*Chronically infected with no clinical signs
*Antibody levels can persist for many years in symptomless animals
*Antibody levels can persist for many years in symptomless animals
Single positive result in rabbit with clinical signs of encephalitozoonosis
===Single positive result in rabbit with clinical signs of encephalitozoonosis===
*Could be active Encephalitozoon cuniculi infection (or other infection causing signs)
*Could be active Encephalitozoon cuniculi infection (or other infection causing signs)
Single negative result in healthy rabbit
===Single negative result in healthy rabbit===
*Could be free from infection
*Could be free from infection
*Could be infected less than 2 weeks ago
*Could be infected less than 2 weeks ago
*Retest in four weeks
*Retest in four weeks
Single negative result in rabbit with clinical signs of encephalitozoonosis
===Single negative result in rabbit with clinical signs of encephalitozoonosis===
*Rules out Encephalitozoon cuniculi infection as the cause of clinical signs
*Rules out ''Encephalitozoon cuniculi'' infection as the cause of clinical signs
*Advise further tests
*Advise further tests
**renal biopsy
**renal biopsy
**MRI/CT scans
**MRI/CT scans
To establish an Encephalitozoon-free colony:
===To establish an Encephalitozoon-free colony===
*Test fortnightly for two months or until all animals are negative for a month, whichever is longer
*Test fortnightly for two months or until all animals are negative for a month, whichever is longer
*Sacrifice any positive cases
*Sacrifice any positive cases
Treatment
===Treatment===
*Albendazole 10 mg/kg q 24 hrs - ?teratogenic (Pollock 2006)
*Albendazole q 24 hrs - ?teratogenic (Pollock 2006)
*Fenbendazole 20 mg/kg q 24 hrs
*Fenbendazole q 24 hrs
*Oxytetracycline 30 mg/kg SC q 72hrs.
*Oxytetracycline SC q 72hrs.
*Three possible therapies – my cocktail is albendazole and oxytetracycline as shown above.
*Three possible therapies – my cocktail is albendazole and oxytetracycline as shown above.
*Vestibular-calming agents
*Vestibular-calming agents
*Environmental disinfection
*Environmental disinfection
*Corticosteroids
*Corticosteroids