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Extrinsic Allergic Bronchio-Alveolitis (view source)
Revision as of 14:19, 11 August 2010
, 14:19, 11 August 2010Created page with "*Synonym: '''Bovine Farmers Lung''' *Arises due to repeated inhalation of spores of thermophilic actinomycetes in mouldy hay (''Micropolyspora faeni a..."
*Synonym: '''Bovine Farmers Lung'''
*Arises due to repeated inhalation of spores of thermophilic [[:Category:Actinomycetes|actinomycetes]] in mouldy hay (''Micropolyspora faeni and Thermactinomyces vulgaris'')
*Can be experimentally reproduced by repeated exposure to ''M. faeni'' aerosols
*Disease primarily of housed animals in winter
*Spores can penetrate to the level of terminal bronchioles and alveoli throughout the lung
*Pathogenesis results from a type III (Arthus) hypersensitivity reaction to the inhaled fungal spores
*Macroscopically:
**Lungs appear normal however on close inspection, numerous small grey nodules representing lymphoid reaction are evident
*Histologically:
**Lymphocytic/plasmacytic bronchitis/ bronchiolitis
**Associated thickening of the alveolar septae
**In severe and chronic disease, the lesions can progress to severe interstitial fibrosis and type II hyperplasia
**In extreme cases, vascular compromise may -> [[Lungs Circulatory - Pathology#Pulmonary hypertension|'''pulmonary hypertension''']] -> [[Cor Pulmonale|'''cor pulmonale''']]
[[Category:Allergic Respiratory Diseases]]
[[Category:Cattle]]
[[Category:To Do - Blood]]
*Arises due to repeated inhalation of spores of thermophilic [[:Category:Actinomycetes|actinomycetes]] in mouldy hay (''Micropolyspora faeni and Thermactinomyces vulgaris'')
*Can be experimentally reproduced by repeated exposure to ''M. faeni'' aerosols
*Disease primarily of housed animals in winter
*Spores can penetrate to the level of terminal bronchioles and alveoli throughout the lung
*Pathogenesis results from a type III (Arthus) hypersensitivity reaction to the inhaled fungal spores
*Macroscopically:
**Lungs appear normal however on close inspection, numerous small grey nodules representing lymphoid reaction are evident
*Histologically:
**Lymphocytic/plasmacytic bronchitis/ bronchiolitis
**Associated thickening of the alveolar septae
**In severe and chronic disease, the lesions can progress to severe interstitial fibrosis and type II hyperplasia
**In extreme cases, vascular compromise may -> [[Lungs Circulatory - Pathology#Pulmonary hypertension|'''pulmonary hypertension''']] -> [[Cor Pulmonale|'''cor pulmonale''']]
[[Category:Allergic Respiratory Diseases]]
[[Category:Cattle]]
[[Category:To Do - Blood]]