Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
Jump to navigation
Jump to search
Diffuse Fibrosing Alveolitis (view source)
Revision as of 14:24, 11 August 2010
, 14:24, 11 August 2010Created page with "Diffuse Fibrosing Alveolitis/ Interstitial Pneumonia *Diffuse inflammatory process which occurs distal to the terminal bronchioles *Characterised by thickening and fibrosis of t..."
Diffuse Fibrosing Alveolitis/ Interstitial Pneumonia
*Diffuse inflammatory process which occurs distal to the terminal bronchioles
*Characterised by thickening and fibrosis of the alveolar walls
*The precise underlying aetiology of this condition is obscure and it is likely to represent the end stage of a variety of initial insults including '''EAA''' and [[Lungs Inflammatory - Pathology#Acute bovine pulmonary emphysema and oedema (ABPEE)|fog fever]]
*Progression from an acute exudative phase through a proliferative phase (proliferation of type II pneumocytes) to a final irreversible stage of fibrosis is the hallmark of DFA
*The rate of the ensuing fibrosis is heavily dependant on the intensity of the inflammation associated with it
*Underlying pathogenesis of the fibrosis is complex and involves a relative increase of type I collagen fibres (dense, high tensile strength) over type III fibres (reticulin)
*Stimulation of fibroblast proliferation and collagen deposition are thought to be induced by macrophage derived cytokines, e.g. IL-1, TGFalpha and TGFbeta, GM-CSF
[[Category:Allergic Respiratory Diseases]][[Category:To Do - Blood]]
*Diffuse inflammatory process which occurs distal to the terminal bronchioles
*Characterised by thickening and fibrosis of the alveolar walls
*The precise underlying aetiology of this condition is obscure and it is likely to represent the end stage of a variety of initial insults including '''EAA''' and [[Lungs Inflammatory - Pathology#Acute bovine pulmonary emphysema and oedema (ABPEE)|fog fever]]
*Progression from an acute exudative phase through a proliferative phase (proliferation of type II pneumocytes) to a final irreversible stage of fibrosis is the hallmark of DFA
*The rate of the ensuing fibrosis is heavily dependant on the intensity of the inflammation associated with it
*Underlying pathogenesis of the fibrosis is complex and involves a relative increase of type I collagen fibres (dense, high tensile strength) over type III fibres (reticulin)
*Stimulation of fibroblast proliferation and collagen deposition are thought to be induced by macrophage derived cytokines, e.g. IL-1, TGFalpha and TGFbeta, GM-CSF
[[Category:Allergic Respiratory Diseases]][[Category:To Do - Blood]]