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Category:Primary Adaptive Immunity Deficiencies (view source)
Revision as of 13:52, 12 August 2010
, 13:52, 12 August 2010Created page with "===Deficiencies of Adaptive Immunity=== ====Equine Severe Combined Immune Deficiency (Equine SCID)==== *Autosomal recessive *Occurs in 2-3% of Arabian foals *Defect in DNA-depen..."
===Deficiencies of Adaptive Immunity===
====Equine Severe Combined Immune Deficiency (Equine SCID)====
*Autosomal recessive
*Occurs in 2-3% of Arabian foals
*Defect in DNA-dependent protein kinase gene
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
*Foals usually die from bronchopneumonia
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
*Affects Basset Hounds and Corgis
*X-linked recessive defect in the gene coding for the IL-2 receptor
**IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate
*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
====Selective [[IgA]] deficiency of German Shepherd Dogs====
*Poorly understood
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
*Unknown aetiology
*Inherited defects
*Low levels of circulating [[Immunoglobulin M|IgM]] and [[Immunoglobulin G|IgG]]
*Impaired [[Neutrophils|neutrophil]] function
*Causes recurrent pyrexia and infections
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
[[Category:Primary Immunodeficiency]]
====Equine Severe Combined Immune Deficiency (Equine SCID)====
*Autosomal recessive
*Occurs in 2-3% of Arabian foals
*Defect in DNA-dependent protein kinase gene
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
*Foals usually die from bronchopneumonia
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
*Affects Basset Hounds and Corgis
*X-linked recessive defect in the gene coding for the IL-2 receptor
**IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate
*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
====Selective [[IgA]] deficiency of German Shepherd Dogs====
*Poorly understood
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
*Unknown aetiology
*Inherited defects
*Low levels of circulating [[Immunoglobulin M|IgM]] and [[Immunoglobulin G|IgG]]
*Impaired [[Neutrophils|neutrophil]] function
*Causes recurrent pyrexia and infections
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
[[Category:Primary Immunodeficiency]]