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Equine Severe Combined Immune Deficiency (view source)
Revision as of 13:54, 12 August 2010
, 13:54, 12 August 2010Created page with "(Equine SCID) *Autosomal recessive *Occurs in 2-3% of Arabian foals *Defect in DNA-dependent protein kinase gene **Gene codes for a DNA repair enzyme involved in V(D)J recombinat..."
(Equine SCID)
*Autosomal recessive
*Occurs in 2-3% of Arabian foals
*Defect in DNA-dependent protein kinase gene
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
*Foals usually die from bronchopneumonia
[[Category:Primary Adaptive Immunity Deficiencies]]
[[Category:To Do - Blood]]
*Autosomal recessive
*Occurs in 2-3% of Arabian foals
*Defect in DNA-dependent protein kinase gene
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
*Foals usually die from bronchopneumonia
[[Category:Primary Adaptive Immunity Deficiencies]]
[[Category:To Do - Blood]]