| Line 3: |
Line 3: |
| | ====[[Equine Severe Combined Immune Deficiency]] ==== | | ====[[Equine Severe Combined Immune Deficiency]] ==== |
| | | | |
| − | ====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)==== | + | ====[[Canine X-Linked Severe Combined Immune Deficiency]] ==== |
| − | *Affects Basset Hounds and Corgis
| + | |
| − | *X-linked recessive defect in the gene coding for the IL-2 receptor
| |
| − | **IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate
| |
| − | *Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
| |
| − | *Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
| |
| − | [[Category:Primary Adaptive Immunity Deficiencies]]
| |
| − | [[Category:To Do - Blood]]
| |
| | ====Selective [[IgA]] deficiency of German Shepherd Dogs==== | | ====Selective [[IgA]] deficiency of German Shepherd Dogs==== |
| | *Poorly understood | | *Poorly understood |
| | *Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis | | *Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis |
| | *[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease | | *[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease |
| − | [[Category:Primary Adaptive Immunity Deficiencies]] | + | [[Category:Primary Adaptive Immunity Deficiencies]][[Category:Dog]] |
| | [[Category:To Do - Blood]] | | [[Category:To Do - Blood]] |
| | ====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds==== | | ====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds==== |
| Line 26: |
Line 20: |
| | **E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]] | | **E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]] |
| | | | |
| − | [[Category:Primary Adaptive Immunity Deficiencies]] | + | [[Category:Primary Adaptive Immunity Deficiencies]][[Category:Dog]] |
| | [[Category:To Do - Blood]] | | [[Category:To Do - Blood]] |
| | | | |