Changes

==Description==

==Description==

Canine distemper is a contagious, febrile disease of canids and other carnivores caused by Canine Distemper Virus. Canine distemper virus is a member of the paramyxoviridae family and the morbillivirus genus, and as such is closely related to the measles, rinderpest and phocine and dolphin distemper viruses.

Canine distemper is a contagious, febrile disease of canids and other carnivores caused by Canine Distemper Virus. Canine distemper virus is a member of the Paramyxoviridae family and the morbillivirus genus, and as such is closely related to the measles, rinderpest and phocine and dolphin distemper viruses. The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope which possesses spiked glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (posititce-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment.

    * Viruses of Paramyxoviridae are enveloped - many are pleomorphic - and have a helical nucleocapsid (see Fig. 18.1).

    * The envelope is covered with spikes whose glycoproteins are responsible for hemagglutinin, neuraminidase, and hemolytic activities.

    * Replication takes place in the cytoplasm and envelopment at the surface (plasma membrane) of infected cells.

    * The ssRNA (-) is used as a template for the production of mRNA (+) and progeny genomes.

    * The viruses are generally sensitive to heat, drying, lipid solvents and many disinfectants.

    * Most can be propagated in embryonated eggs and in cell cultures with the production of cytopathic effects including syncytia and cytoplasmic inclusions.

 

*[[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|Rhinitis]]

*[[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|Rhinitis]]