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Microscopic lesions are widespread in organs and the brain. Characteristic viral inclusion bodies are commonly found in brain, lung, stomach, and urinary bladder.
Microscopic lesions are widespread in organs and the brain. Characteristic viral inclusion bodies are commonly found in brain, lung, stomach, and urinary bladder.
*May present as series of infections
*'''Immunocytochemistry''' of inclusion bodies
**Intracytoplasmic inclusions may be found in most affected tissues
**Inclusions persist longest in the brain (may be intranuclear) and the alveolar macrophages
**Sections of fixed bronchial tissue, lung, macrophages, bladder may be used or nasal or conjunctival epithelium from live animals
*Giant cells may be seen in the alveol
* Microscopic lesions of demyelination in the cerebellum and characteristic inclusion bodies in various tissues are diagnostically significant. The inclusions are primarily intranuclear in the brain and intracytoplasmic in other tissues.
* The prognosis is poor for dogs with CNS involvement.
*[[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|Rhinitis]]
*[[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|Rhinitis]]