Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
Jump to navigation
Jump to search
Adaptive Immunity to Viruses (view source)
Revision as of 13:31, 16 August 2010
, 13:31, 16 August 2010Created page with "thumb|200px|right|'''''' '''Humoral''' *Production of '''neutralising antibody''' *'''Antibody-dependent cell mediated cytotoxicity (ADCC)''' [[Immuno..."
[[Image:ImageNeeded.png|thumb|200px|right|'''''']]
'''Humoral'''
*Production of '''neutralising antibody'''
*'''Antibody-dependent cell mediated cytotoxicity (ADCC)'''
[[Immunoglobulins|Antibody]]-labelled cells can be targeted by [[Lymphocytes#Natural Killer (NK) cells|NK Cells]] as another defence against viral infection. Antibody produced against viral protein can attach to infected cells during their budding phase, which effectively labels them for [[Lymphocytes#Natural Killer (NK) cells|NK]] targeting. [[Lymphocytes#Natural Killer (NK) cells|NK]] cells express Fcγ receptors with which to detect such cells. Once activated, they release a host of enzymes to induce apoptosis of the budding cell.
'''Cell-Mediated'''
*[[Lymphocytes#Cytotoxic CD8+|CD8+ T-cell]] mediated killing of virus infected cells
**Main cells involved in the immune response to '''intracellular''' virus infection
**Recognition of [[MHC - WikiBlood#MHC I|MHC I]]-peptide complex
**Infected cells are killed by apoptosis
***Perforin and granzymes activate the caspase cascade
***Fas-ligand triggers the Fas-mediated apoptosis pathway
***Cytotoxic [[Cytokines - WikiBlood|cytokines]] (especially TNF-α & TNF-β lymphotoxin) act on TNF receptors to induce programmed cell death
<big>'''Also see [[Immunity to Viruses]]'''</big>
[[Category:To Do - Blood]]
'''Humoral'''
*Production of '''neutralising antibody'''
*'''Antibody-dependent cell mediated cytotoxicity (ADCC)'''
[[Immunoglobulins|Antibody]]-labelled cells can be targeted by [[Lymphocytes#Natural Killer (NK) cells|NK Cells]] as another defence against viral infection. Antibody produced against viral protein can attach to infected cells during their budding phase, which effectively labels them for [[Lymphocytes#Natural Killer (NK) cells|NK]] targeting. [[Lymphocytes#Natural Killer (NK) cells|NK]] cells express Fcγ receptors with which to detect such cells. Once activated, they release a host of enzymes to induce apoptosis of the budding cell.
'''Cell-Mediated'''
*[[Lymphocytes#Cytotoxic CD8+|CD8+ T-cell]] mediated killing of virus infected cells
**Main cells involved in the immune response to '''intracellular''' virus infection
**Recognition of [[MHC - WikiBlood#MHC I|MHC I]]-peptide complex
**Infected cells are killed by apoptosis
***Perforin and granzymes activate the caspase cascade
***Fas-ligand triggers the Fas-mediated apoptosis pathway
***Cytotoxic [[Cytokines - WikiBlood|cytokines]] (especially TNF-α & TNF-β lymphotoxin) act on TNF receptors to induce programmed cell death
<big>'''Also see [[Immunity to Viruses]]'''</big>
[[Category:To Do - Blood]]