Changes

*'''Endogenous vaccines''' are where the antigens are made as new proteins by the cell, bacterium or virus  

*'''Endogenous vaccines''' are where the antigens are made as new proteins by the cell, bacterium or virus  

**Involves [[MHC - WikiBlood#MHC I|MHC class I]] processing

**Involves [[Major Histocompatability Complexes#MHC I|MHC class I]] processing

**E.g. live virus, recombinant virus and DNA vaccines

**E.g. live virus, recombinant virus and DNA vaccines

*'''Exogenous vaccines''' are when the antigen is processed from the outside by endocytosis without any new proteins being made by the host cell  

*'''Exogenous vaccines''' are when the antigen is processed from the outside by endocytosis without any new proteins being made by the host cell  

**involves [[MHC - WikiBlood#MHC II|MHC class II]] processing

**involves [[Major Histocompatability Complexes#MHC II|MHC class II]] processing

**E.g. Inactivated and subunit vaccines

**E.g. Inactivated and subunit vaccines

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins|'''antibody''']]

*Immunity for the extracellular phase requires neutralising [[Immunoglobulins|'''antibody''']]

**[[Lymphocytes#B Cells|B cells]] needed

**[[Lymphocytes#B Cells|B cells]] needed

**[[T cell differentiation#TH2 Cells|T helper type II cells]] needed (for the [[MHC - WikiBlood#MHC II|MHC class II pathway]])

**[[T cell differentiation#TH2 Cells|T helper type II cells]] needed (for the [[Major Histocompatability Complexes#MHC II|MHC class II pathway]])

**Live vaccine can be used

**Live vaccine can be used

**Killed vaccine can be used

**Killed vaccine can be used

*Immunity for the intracellular phase requires [[Lymphocytes#Cytotoxic CD8+|'''CD8+ cytotoxic T cells''']]

*Immunity for the intracellular phase requires [[Lymphocytes#Cytotoxic CD8+|'''CD8+ cytotoxic T cells''']]

**[[MHC - WikiBlood#MHC I|MHC class I pathway]]

**[[Major Histocompatability Complexes#MHC I|MHC class I pathway]]

**Only live vaccine can be used to get into cells (entering via the endogenous pathway)

**Only live vaccine can be used to get into cells (entering via the endogenous pathway)