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Created page with "<p> High endothelial venules (HEV) are composed of cuboidal/columnar epithelium and are the major route for lymphocytes to enter the node. HEV contain a large number of aquaporin..."
<p> High endothelial venules (HEV) are composed of cuboidal/columnar epithelium and are the major route for lymphocytes to enter the node. HEV contain a large number of aquaporin-1 channels allowing for a large uptake of water which in turn drives lymph flow through the cortex. This fluid is then returned direct to the bloodstream. The venules are the source of most of the node's [[Lymphocytes#T cells|T cells]] and [[Lymphocytes#B cells|B cells]] and express selectins (receptors for lymphocytes primed with antigens).</p>
<p>HEV express CD34 and GlyCAM-1 which bind to L-selectin on naive lymphocytes. This allows circulating [[Lymphocytes|lymphocytes]] to recognise when they have reached a [[:Category:Secondary Lymphoid Tissue|secondary lymphoid organ]] and they leave the bloodstream, entering the lymphatic tissue.</P>
[[Category:Lymph Nodes]][[Category:Lymphocytes]]
<p>HEV express CD34 and GlyCAM-1 which bind to L-selectin on naive lymphocytes. This allows circulating [[Lymphocytes|lymphocytes]] to recognise when they have reached a [[:Category:Secondary Lymphoid Tissue|secondary lymphoid organ]] and they leave the bloodstream, entering the lymphatic tissue.</P>
[[Category:Lymph Nodes]][[Category:Lymphocytes]]