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Disseminated Intravascular Coagulation (view source)

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DIC has a poor prognosis with a high mortality rate.

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* Disseminated intravacular coagulation is a widespread intravascular coagulation of the microcirculation.

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* The capillaries are principally affected.

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* There are various causes.

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** Mismatched blood transfusion

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** Acute haemolytic crises

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** Extensive burns and trauma

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** Infectious and post-infectious immunologic reactions.

* There is widespread occlusion of the microcirculation with small white thrombi.

** May cause [[Shock|shock]], acute respiratory distress, heart failure or renal failure.

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* Haemorrhagic diathesis may develop.

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** Is a result of rapid consumption and depletion of fibrinogen, platelets and clotting factors

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* The fibrinolytic system is also highly stimulated to prevent what little clotting activity that remains.

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