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Equine Severe Combined Immune Deficiency (view source)
Revision as of 12:41, 18 August 2010
, 12:41, 18 August 2010Text replace - "[[Lymphocytes|" to "[[Lymphocytes - Introduction|"
*Occurs in 2-3% of Arabian foals
*Occurs in 2-3% of Arabian foals
*Defect in DNA-dependent protein kinase gene
*Defect in DNA-dependent protein kinase gene
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes - Introduction|lymphocytes]] (e.g. Ig and TCR)
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)