Changes

*Diseases that cause '''increased destruction of platelets'''

*Diseases that cause '''increased destruction of platelets'''

**'''[[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]]''' is a common autoimmune disease that leads to the destruction of platelets by cell of the monocyte phagocyte system (MPS).

**'''[[Immune Mediated Thrombocytopaenia|Immune-mediated thrombocytopaenia]]''' is a common autoimmune disease that leads to the destruction of platelets by cell of the monocyte phagocyte system (MPS).

**'''Infectious diseases''' that cause destruction of platelets include [[Bovine Viral Diarrhoea Virus|bovine viral diarrhoea]], [[Classical Swine Fever|classical swine fever]] and [[Infectious Canine Hepatitis|infectious canine hepatitis]].  The parasites ''[[Ehrlichia platys]]'', ''[[Anaplasma phagocytophilum]]'' and ''[[Ehrlichia canis]]'' may also cause infectious thrombocytopaenia.  Any severe bacterial infection, including those caused by [[:Category:Staphylococcus species|''Staphylococci'']] and the Gram negative bacteria that produce endotoxin (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas spp.'']] or [[Salmonella|''Salmonella spp.'']]) may also result in the destruction of platelets.

**'''Infectious diseases''' that cause destruction of platelets include [[Bovine Viral Diarrhoea Virus|bovine viral diarrhoea]], [[Classical Swine Fever|classical swine fever]] and [[Infectious Canine Hepatitis|infectious canine hepatitis]].  The parasites ''[[Ehrlichia platys]]'', ''[[Ehrlichia phagocytophila|Anaplasma phagocytophilum]]'' and ''[[Ehrlichia canis]]'' may also cause infectious thrombocytopaenia.  Any severe bacterial infection, including those caused by [[:Category:Staphylococcus species|''Staphylococci'']] and the Gram negative bacteria that produce endotoxin (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas spp.'']] or [[Salmonella|''Salmonella spp.'']]) may also result in the destruction of platelets.

*Diseases that cause '''sequestration of platelets''' usually involve some enlargement of the spleen as this is the major organ where platelets are stored outside of the circulation.  Examples include:

*Diseases that cause '''sequestration of platelets''' usually involve some enlargement of the spleen as this is the major organ where platelets are stored outside of the circulation.  Examples include:

**[[Haemangiosarcoma]] of the spleen and liver

**[[Haemangiosarcoma]] of the spleen and liver

==Thrombocytopathia==

==Thrombocytopathia==

Defects in platelet function may be congenital defects or they may be acquired with a number of diseases.  Congenital thrombocytopathias are rare inherited diseases which are characterised by defects in platelet adhesiveness, aggregation and factor release.  The defects are usually associated with particular breeds, such as Chediak-Higashi syndrome in blue smoke Persian cats.

 

* A rare inherited condition.

* Recorded in the dog.   

 

* Characterised by defective thrombocyte formation.

==Thrombocytosis==

==Thrombocytosis==