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===Clinical Signs===

===Clinical Signs===

Most healthy humans that become infected with ''Toxoplasma gondii'' have few symptoms and fully recover. However, when clinical disease does occur, there are several manifestations.  

There are several manifestations of toxoplasmosis in man. Acute infection in healthy individuals is normally asymptomatic, but up to 20% of patient develop lymphadenopathy. This is sometimes accompanied by flu-like signs which may include pyrexia, pharyngitis and myalgia and last for several weeks before a full recovery is made.

Acute toxoplasmosis: Acute infection is usually asymptomatic, but 10 to 20% of patients develop bilateral, nontender cervical or axillary lymphadenopathy. A few of these also have a mild flu-like syndrome of fever, malaise, myalgia, hepatosplenomegaly, and less commonly, pharyngitis, which may mimic infectious mononucleosis. Atypical lymphocytosis, mild anemia, leukopenia, and slightly elevated liver enzymes are common. The syndrome may persist for weeks but is almost always self-limited.

CNS toxoplasmosis: Most patients with AIDS or other immunocompromised patients who develop toxoplasmosis due to reactivation present with ring-enhancing intracranial mass lesions or encephalitis. These patients typically have headache, altered mental status, seizures, coma, fever, and sometime focal neurologic deficits, such as motor or sensory loss, cranial nerve palsies, visual abnormalities, and focal seizures.

CNS toxoplasmosis: Most patients with AIDS or other immunocompromised patients who develop toxoplasmosis due to reactivation present with ring-enhancing intracranial mass lesions or encephalitis. These patients typically have headache, altered mental status, seizures, coma, fever, and sometime focal neurologic deficits, such as motor or sensory loss, cranial nerve palsies, visual abnormalities, and focal seizures.