Changes

When ''Culicoides'' feed on a bluetongue-infected host, they become persistently infected with the virus for the duration of their lives⁴. The global distribution of BTV is related only to these competent insect vectors²: although vertical and venereal transmission of bluetongue is possible, these routes do not influence the epidemiology of BTV. The vector species varies with location and is poorly characterised in some areas, including northern Europe. However, as described above, it has been demonstratated that ambient temperature has profound effects on vector survival and feeding activity, and the replication of BTV in the insect⁶. Therefore, the relationship between temperature and effective transmission of BTV is likely to be a limiting factor to the spread of BTV, which may potentially be overcome by global warming.

When ''Culicoides'' feed on a bluetongue-infected host, they become persistently infected with the virus for the duration of their lives⁴. The global distribution of BTV is related only to these competent insect vectors²: although vertical and venereal transmission of bluetongue is possible, these routes do not influence the epidemiology of BTV. The vector species varies with location and is poorly characterised in some areas, including northern Europe. However, as described above, it has been demonstratated that ambient temperature has profound effects on vector survival and feeding activity, and the replication of BTV in the insect⁶. Therefore, the relationship between temperature and effective transmission of BTV is likely to be a limiting factor to the spread of BTV, which may potentially be overcome by global warming.

It is appears that in different regions of the world, specific strains of bluetongue virus exists have co-evolved with vector species of insect vector⁷. Thus, in the Americas, the serotypes of BTV that circulate in the United States are different from those in adjacent regions of the Caribbean and Central America, despite the lack of any substantial geographic barrier between the regions. The essential difference lies in the different species of vector insects in the 2 regions: Culicoides sonorensis is the vector of BTV serotypes 10, 11, 13 and 17 in the United States, whereas Culicoides insignis is the vector of BTV serotypes 1, 2, 3, 4, 6, 8, 11, 12, 13, 14 and 17 in the Caribbean and Central/South America. Movement of animals between the 2 regions has not altered the very different constellations of BTV serotypes that occur in each.

It is appears that in different regions of the world, specific serotypes of bluetongue virus have co-evolved with vector species of insect vector⁷. For example, different serotypes of BTV are prevalent in the USA to those in those the Caribbean and Central America although there is no real geographic barrier separating these areas, and animals move between the regions. This is thought to be due to the variation in the species of vector insects: ''Culicoides sonorensis'' is the primary vector in the USA and is most competent for serotypes 10, 11, 13 and 17, but in the Caribbean and Central America ''C. insignis'' carries serotypes 1, 2, 3, 4, 6, 8, 11, 12, 13, 14 and 17⁴.  

 

A variety of other hosts have been implicated in the lifecycle of BTV infection. Serological evidence indicates that large African carnivores are infected with BTV, whereas smaller predators that co-habit with them are not, suggesting that large carnivores are infected through feeding on BTV-infected ruminants [2]. Inadvertent contamination of a canine vaccine with BTV confirmed that dogs are susceptible to BTV infection, indeed pregnant bitches that received this contaminated vaccine typically aborted and died [1]. There is no evidence, however, that dogs or other carnivores are important to the natural cycle of BTV infection.

A variety of other hosts have been implicated in the lifecycle of BTV infection. Serological evidence indicates that large African carnivores are infected with BTV, whereas smaller predators that co-habit with them are not, suggesting that large carnivores are infected through feeding on BTV-infected ruminants [2]. Inadvertent contamination of a canine vaccine with BTV confirmed that dogs are susceptible to BTV infection, indeed pregnant bitches that received this contaminated vaccine typically aborted and died [1]. There is no evidence, however, that dogs or other carnivores are important to the natural cycle of BTV infection.