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Anticoagulant Rodenticide Toxicity (view source)
Revision as of 12:36, 23 August 2010
, 12:36, 23 August 2010→Treatment
contraindicated, as is the administration of agents by
contraindicated, as is the administration of agents by
intramuscular injection.
intramuscular injection.
If ingestion was recent (in past three hours) induce vomiting. Stomach lavage may also be indicated if dogs fail
to vomit. Coumarin rodenticide preparations are often in the form of blue or green granules.
*Give the specific antidote - vitamin K. Phytomenadione, a vitamin K1 analogue available as tablets or injection
(Konakion; Roche), is the drug of choice and reverses low prothrombin levels in 30 minutes. Menadiol (Synkavit; Roche)
is a synthetic K3 and is not as effective.
Dose. 2 - 5 to 10 mg three times daily orally for five days because most coumarins are metabolised and excreted slowly
over two to four days, and longer in some instances.
If clinical signs are severe can give 5 mg intravenously over six to eight hours. However, as anaphalactic reactions
to intravenous administration have been reported in the dog intramuscular route is preferable.
*Give a whole blood transfusion - this replaces the clotting factors as well as replacing blood loss through haemorrhage.
==Prognosis==
==Prognosis==