Changes

===Mechanism of Toxicity===

===Mechanism of Toxicity===

The circulatory system is a very dynamic tissue, which is in a continual state of repair and regeneration. The hemorrhage that occurs as a result of either normal activities or from various insults (trauma, infectious processes, shock, stress, malignancy, etc.) is arrested through an ordered interaction involving 3 major events.

Normally, haemostastis is maintained by three key events.

The first phase is comprised of the platelet adhesion reaction in which activated platelets become sticky, attach to exposed endothelial connective tissue elements and build by aggregation to form a platelet plug. In the second phase, the so-called platelet release reaction, vasoactive and coagulation-triggering substances are released. The damaged vessel retracts, and the third phase, the coagulation mechanism by which soluble fibrinogen is converted to insoluble polymerized fibrin, is triggered.

The first phase is comprised of the platelet adhesion reaction in which activated platelets become sticky, attach to exposed endothelial connective tissue elements and build by aggregation to form a platelet plug. In the second phase, the so-called platelet release reaction, vasoactive and coagulation-triggering substances are released. The damaged vessel retracts, and the third phase, the coagulation mechanism by which soluble fibrinogen is converted to insoluble polymerized fibrin, is triggered.