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Anticoagulant Rodenticide Toxicity (view source)
Revision as of 15:22, 23 August 2010
, 15:22, 23 August 2010→Mechanism of Toxicity
===Mechanism of Toxicity===
===Mechanism of Toxicity===
[[Image:Coagulation Cascade.jpg|thumb|right|250px|Coagulation cascade. Source: Wikimedia Commons; Author: Joe D (2007)]]
[[Image:Coagulation Cascade.jpg|thumb|right|300px|Coagulation cascade. Source: Wikimedia Commons; Author: Joe D (2007)]]
Normally, haemostastis is maintained by three key events<sup>3</sup>. Firstly, platelets are activated, adhere to endothelial connective tissue and aggregate to form a platelet plug. Next, substances are released that trigger coagulation and vasoconstriction. Finally, fibrinogen is polymerised to fibrin which reinforces the platelet plug. Some components of the coagulation and fibrin formation stages are dependent on vitamin K, and it is these which are influenced by anticoagulant rodenticide activity.
Normally, haemostastis is maintained by three key events<sup>3</sup>. Firstly, platelets are activated, adhere to endothelial connective tissue and aggregate to form a platelet plug. Next, substances are released that trigger coagulation and vasoconstriction. Finally, fibrinogen is polymerised to fibrin which reinforces the platelet plug. Some components of the coagulation and fibrin formation stages are dependent on vitamin K, and it is these which are influenced by anticoagulant rodenticide activity.