Changes

==Treatment==

==Treatment==

Treatment of anticoagulant rodenticide poisoning must

The treatment of anticoagulant rodenticide poisoning aims to correct the hypovolaemia and coagulopathy. A whole blood or plasma tranfusion provides immediate access to vitamin K dependent clotting factors and helps to restore blood volume^1-9. This may need to be followed with larger volumes of crystalloids to compensate for large volumes of fluid loss. The specific treatment of anticoagulant rodenticide toxicosis is administration of vitamin K₁. This is given as a subcutaneous loading dose at 5mg/kg, and is followed by oral or subcutaneous administration at 1.25-2.5mg/kg once daily, for 1-6 weeks. If given ''per os'', giving a small amount of fat such as canned dog food aids absorption⁷. Intravenous administration of vitamin K₁ is contraindicated as anaphylactic reactions may occur. Treatment with vitamin K₃ is also contraindicated as it is not efficatious in the face of anticoagulant rodenticide toxicity.  

be supportive in nature and is directed at correcting the

hypovolaemia and coagulopathy. Fresh blood or plasma

will help to correct the hypovolaemia and enhance

haemostasis by restoring depleted clotting factors.

Vitamin K1 (5 mg/kg) should be given as a loading dose

Vitamin K1 (5 mg/kg) should be given as a loading dose

subcutaneously at multiple sites, followed by subcutaneous

subcutaneously at multiple sites, followed by subcutaneous